tatAY
168
component of the [protein|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY]-[protein|E60FC9C9B273DD6B07B7B95819525DE5F35113CE|tatCY] twin-arginine translocase
locus
BSU_05980
Molecular weight
5.93 kDa
pI
6.56
function
TAT [wiki|protein secretion]
product
component of the twin-arginine translocation pathway
essential
no
synonyms
tatAY, ydiI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1826 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
647,760 647,933
The protein
Catalyzed reaction/ biological activity
secretion of [protein|3985F88334D7B034A66473C5BB39188AB61A65F6|efeB] and of [protein|253A24EEA02C07E577A96FB64DF39F9A3D0C3A52|ykuE]
delivers [protein|D4AF96C936093BA44E46FF92A3EDE437495B0923|qcrA] to the membrane [Pubmed|23256564]
Protein family
TatA/E family (with [protein|8987552EFDF673776741405F7F5FE004556484CA|tatAC] and [protein|E4395255CD43ACB611E0BA872182DF801662C366|tatAD], according to UniProt)
Structure
[PDB|2L16] ([protein|E4395255CD43ACB611E0BA872182DF801662C366|tatAD], 60% identity) [pubmed|20726548]
[AF|O05522]
Paralogous protein(s)
[protein|8987552EFDF673776741405F7F5FE004556484CA|tatAC], [protein|E4395255CD43ACB611E0BA872182DF801662C366|tatAD]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Additional information
[protein|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY]-[protein|E60FC9C9B273DD6B07B7B95819525DE5F35113CE|tatCY]-dependent export of [protein|253A24EEA02C07E577A96FB64DF39F9A3D0C3A52|ykuE] and [protein|3985F88334D7B034A66473C5BB39188AB61A65F6|efeB] requires a functional [protein|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA] [Pubmed|23180473]
Expression and Regulation
Operons
genes
[gene|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY]-[gene|E60FC9C9B273DD6B07B7B95819525DE5F35113CE|tatCY]
description
[Pubmed|22383849]
regulation
constitutitvely expressed [Pubmed|22383849]
genes
[gene|4A8D74B83E20FA138ED66F0D8FD456B69B740D92|ydiG]-[gene|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]-[gene|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY]-[gene|E60FC9C9B273DD6B07B7B95819525DE5F35113CE|tatCY]
description
[Pubmed|22383849]
regulation
constitutitvely expressed [Pubmed|22383849]
the mRNA is processed between [gene|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex] and [gene|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
Biological materials
Mutant
MGNA-C202 (ydiI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2200 NBRP B. subtilis, Japan]
BKE05980 ([gene|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTGGGCTCCTCCTTT, downstream forward: _UP4_AAGAAAGAAGATCAGTAAGT
BKK05980 ([gene|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTGGGCTCCTCCTTT, downstream forward: _UP4_AAGAAAGAAGATCAGTAAGT
labs
[wiki|Jan Maarten van Dijl], University of Groningen, The Netherlands, [https://www.rug.nl/staff/j.m.van.dijl/ Homepage]
References
Reviews
Original Publications
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Time of last update: 2024-10-12 16:20:21
Author of last update: Jstuelk