folE

folE
168

GTP cyclohydrolase I, required for the initial step of queuosine synthesis ([wiki|tRNA modification])

locus
BSU_22780
Molecular weight
21.07 kDa
pI
6.34
Protein length
Gene length
function
biosynthesis of folate and queuosine
product
GTP cyclohydrolase IA
essential
yes
ec
3.5.4.16
synonyms
folE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0302 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,384,783  2,385,355
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
GTP + H2O --> 7,8-dihydroneopterin 3'-triphosphate + formate + H+ (according to UniProt)
Protein family
GTP cyclohydrolase I family (with [protein|5F96500CC46CC4DAECEBAD34EC50B10548E6D0F9|queF], according to UniProt)
[wiki|Cofactors]
zinc-dependent enzyme [Pubmed|19767425]
Structure
[PDB|3D2O] (enzyme from ''Neisseria gonorrhoeae'') [Pubmed|17032654]
[AF|P19465]
Effectors of protein activity
the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity [pubmed|31132310]
Expression and Regulation
Operons
genes
[gene|7732A37D59E2643F232F2C0AFE51BCF7A79EDE29|folE]-[gene|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]
description
[Pubmed|2123343]
regulation
constitutive [Pubmed|19767425]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2123343], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|7732A37D59E2643F232F2C0AFE51BCF7A79EDE29|folE]→[gene|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]

2024-09-03 09:40:25

ghost

71

f1bc4bf9e927d1361809ff8aa78e71d66480a04b

86F7072792D249A1DF96784E3FA8EB41E1A5BB8F

References
Reviews
31220391
Original Publications
1551827,2123343,17032654,19767425,28189581,31132310

7732A37D59E2643F232F2C0AFE51BCF7A79EDE29

Page visits: 2989

Time of last update: 2024-10-04 09:15:05

Author of last update: Jstuelk