folE
168
GTP cyclohydrolase I, required for the initial step of queuosine synthesis ([wiki|tRNA modification])
locus
BSU_22780
Molecular weight
21.07 kDa
pI
6.34
function
biosynthesis of folate and queuosine
product
GTP cyclohydrolase IA
essential
yes
ec
3.5.4.16
synonyms
folE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0302 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,384,783 2,385,355
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
GTP + H2O --> 7,8-dihydroneopterin 3'-triphosphate + formate + H+ (according to UniProt)
Protein family
GTP cyclohydrolase I family (with [protein|5F96500CC46CC4DAECEBAD34EC50B10548E6D0F9|queF], according to UniProt)
[wiki|Cofactors]
zinc-dependent enzyme [Pubmed|19767425]
Structure
[PDB|3D2O] (enzyme from ''Neisseria gonorrhoeae'') [Pubmed|17032654]
[AF|P19465]
Effectors of protein activity
the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity [pubmed|31132310]
Expression and Regulation
Operons
genes
[gene|7732A37D59E2643F232F2C0AFE51BCF7A79EDE29|folE]-[gene|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]
description
[Pubmed|2123343]
regulation
constitutive [Pubmed|19767425]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2123343], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
Reviews
Original Publications
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Time of last update: 2024-12-30 23:35:09
Author of last update: Jstuelk