hemE
168
uroporphyrinogen decarboxylase (uroporphyrinogen III)
locus
BSU_10120
Molecular weight
39.49 kDa
pI
5.26
function
heme biosynthesis
product
uroporphyrinogen decarboxylase (uroporphyrinogen III)
essential
no
ec
4.1.1.37
synonyms
hemE, uroD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0407 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,086,117 1,087,178
The protein
Catalyzed reaction/ biological activity
4 H+ + uroporphyrinogen III --> 4 CO2 + coproporphyrinogen III (according to UniProt)
Protein family
uroporphyrinogen decarboxylase family (single member, according to UniProt)
Structure
[PDB|2INF]
[AF|P32395]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]-[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]-[gene|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6|hemY]
description
[Pubmed|1459957]
Biological materials
Mutant
BKE10120 ([gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGATTTCCACCTTTCA, downstream forward: _UP4_TAAGCATATCTTTTGGTATC
BKK10120 ([gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGATTTCCACCTTTCA, downstream forward: _UP4_TAAGCATATCTTTTGGTATC
References
Reviews
Original Publications
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Time of last update: 2025-04-09 20:54:10
Author of last update: Jstuelk