htrC
168
similar to quality control membrane serine protease [protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|htrA]
locus
BSU_40360
Molecular weight
42.63 kDa
pI
5.32
function
unknown
product
putative quality control membrane protease
essential
no
synonyms
htrC, yycK, yyxA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0265 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,147,567 4,148,769
The protein
Protein family
Peptidase S1C family (with [protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|htrA] and [protein|796216BE9CD6DADFEADC29497253C81BF496A2ED|htrB], according to UniProt)
[wiki|Domains]
transmembrane helix (aa 22 - 42) (according to UniProt)
[wiki|PDZ domain] (aa 295 - 392) (according to UniProt)
Structure
[PDB|3QO6] (from Arabidopsis thaliana, 37% identity) [pubmed|21532594]
[AF|P39668]
Paralogous protein(s)
[protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|htrA]
[wiki|Localization]
inner spore membrane [Pubmed|26731423]
Expression and Regulation
Operons
genes
[gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]
description
[Pubmed|9829949]
regulation
''htrC'' transcript expressed during sporulation [Pubmed|9829949]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|9829949], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
genes
[gene|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]-[gene|E88978809272FAC2520DB4ABCA0554F8028F3451|walK]-[gene|06D2D03C65D50E3909B2C93835193815B6016967|walH]-[gene|EE681C9A42FCC29CBB55CC9566EE4CFF986D0F1D|walI]-[gene|D5321F707E183E72B225F1CED2F2FDCB1183B88A|walJ]-[gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]
description
[Pubmed|9829949]
regulation
''htrC'' transcript expressed during sporulation [Pubmed|9829949]
Biological materials
Mutant
MGNA-B823 (yycK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1822 NBRP B. subtilis, Japan]
BKE40360 ([gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40360 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCCATCCTTTCCAAG, downstream forward: _UP4_TAATAAAAGCAGTCTGGCAT
BKK40360 ([gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40360 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCCATCCTTTCCAAG, downstream forward: _UP4_TAATAAAAGCAGTCTGGCAT
References
Reviews
Original Publications
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Time of last update: 2024-10-12 17:05:04
Author of last update: Jstuelk