hemN
168
anaerobic coproporphyrinogen III oxidase
locus
BSU_25500
Molecular weight
41.40 kDa
pI
5.53
function
heme biosynthesis
product
anaerobic coproporphyrinogen III oxidase
essential
no
synonyms
hemN, yqeR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0635 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,629,718 2,630,857
The protein
Protein family
anaerobic coproporphyrinogen-III oxidase family (with [protein|5A1E474D2A6043ACF0DF00FEA7F66BFB1332C691|hemZ], according to UniProt)
[wiki|Cofactors]
Fe-S cluster [pubmed|29292548]
SAM (according to UniProt)
Structure
[PDB|1OLT] (from E. coli, 26% identity) [pubmed|14633981]
[AF|P54304]
Paralogous protein(s)
[protein|5A1E474D2A6043ACF0DF00FEA7F66BFB1332C691|hemZ]
Expression and Regulation
Operons
genes
[gene|3744083E3BB30A64D15360A12636665F76C40327|lepA]-[gene|757C51296E198849EAC1FFA4D37121D9085930A8|hemN]
description
[Pubmed|8757728]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9371469], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
There is a terminator between '[protein|search|lepA]' and '[protein|search|hemN]' with only little readthrough
Biological materials
Mutant
BKE25500 ([gene|757C51296E198849EAC1FFA4D37121D9085930A8|hemN]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE25500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACGGATTCACCTTCTTTA, downstream forward: _UP4_TAATTGACATTTTTCTTGTG
BKK25500 ([gene|757C51296E198849EAC1FFA4D37121D9085930A8|hemN]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK25500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACGGATTCACCTTCTTTA, downstream forward: _UP4_TAATTGACATTTTTCTTGTG
References
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Time of last update: 2025-01-26 08:51:06
Author of last update: Melvin.boenninger