ytxM
168
similar to prolyl aminopeptidase
locus
BSU_30810
Molecular weight
30.55 kDa
pI
7.18
function
ubiquinone and menaquinone biosynthesis
product
unknown
essential
no
ec
4.2.99.20
synonyms
ytxM, ytfB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0596 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,149,751 3,150,575
The protein
Catalyzed reaction/ biological activity
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate --> (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate (according to UniProt)
Protein family
[wiki|AB hydrolase superfamily] (according to UniProt)
[wiki|Domains]
[wiki|AB hydrolase-1 domain] (aa 26-259) (according to UniProt)
Structure
[PDB|2XMZ] (from ''Staphylococcus aureus'', 34% identity) [Pubmed|21513522]
[AF|P23974]
Expression and Regulation
Operons
genes
[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]-[gene|E3283812B7EB374EAC8722ECCE28432DE24B7B4C|menD]-[gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]-[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163,8550504]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Biological materials
Mutant
MGNA-A283 (ytxM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/283 NBRP B. subtilis, Japan]
BKE30810 ([gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GACACCATCTGATACCGTTA, downstream forward: _UP4_TGACTCATTCACATAGAGAA
BKK30810 ([gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GACACCATCTGATACCGTTA, downstream forward: _UP4_TGACTCATTCACATAGAGAA
References
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Time of last update: 2025-04-06 20:35:11
Author of last update: Melvin.boenninger