dnaX
168
DNA polymerase III (gamma and tau subunits) part of the clamp-loader complex and the [wiki|replisome]
locus
BSU_00190
Molecular weight
62.53 kDa
pI
5.49
function
[category|SW.3.1.1|DNA replication]
product
DNA polymerase III (gamma and tau subunits)
essential
yes
ec
2.7.7.7
synonyms
dnaX, dnaH, dna-8132
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2812 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
26,814 28,505
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
deoxyribonucleoside 5'-triphosphate + DNA(n) --> diphosphate + DNA(n+1) (according to UniProt)
required for bacteriophage SPP1 replication [Pubmed|23268446]
Protein family
DnaX/STICHEL family (single member, according to UniProt)
Structure
[PDB|1JR3] (from ''E. coli'', 39% identity) [Pubmed|11525729]
[AF|P09122]
[wiki|Localization]
forms foci [Pubmed|21958350]
Nucleoid (Mid-cell) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|73D063EDC412F7F28DA27C986ECCCD1C4A1F6618|dnaX]-[gene|9AFCEFE83560B1E2B1FFD7CFD2E4F17FAE137889|yaaK]-[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]-[gene|C5127208E7562F09249112240F0BE8C582B2E5AD|yaaL]-[gene|CB5D3A2E5BEE336539BEB2D7C5D9C3A63C78FD01|bofA]
description
[Pubmed|22383849]
References
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Time of last update: 2024-12-22 02:43:02
Author of last update: Jstuelk