yhxD
168
general stress protein, similar to alcohol dehydrogenase
locus
BSU_10430
Molecular weight
31.76 kDa
pI
4.54
function
survival of salt and ethanol stresses
product
unknown
essential
no
synonyms
yhxD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,117,734 1,118,633
The protein
Protein family
[wiki|Short-chain dehydrogenases/reductases (SDR) family] (according to UniProt)
Structure
[PDB|3R3S] (from ''Salmonella Enterica'', 66% identity)
[AF|P40398]
Paralogous protein(s)
[protein|0DD474462720CAEE2AE17017BD7CA385238EBC6F|yxbG], [protein|20A7DBA142F3BF8DCAD9732BD908CE8CC79AA993|bacC], [protein|439B468A13137000FB42E9389391CB4986FFED84|fabG]
[protein|B6FF689E65906186F3576B378650D713DB84EDDA|ycdF], (31,1%)
[protein|CA4597C6253CCF7D7954686A30AF041808BDF8E5|gdh], (33,5%)
[protein|EAEEA4DD9641919830A81185333A2610B964D37C|yhdF], (47%)
[protein|3161519994609DA9360ED6E073E4A4C8C6210EFB|ydaD], (48,8%)
[protein|4DEFC2998464BF8327578C36A13A10DD277F991E|ykvO], (34,5%)
[protein|6047F2493FCE3D2A9BDB1AD88E5926ECEED81036|yhxC], (45,2%),
Expression and Regulation
Operons
genes
[gene|739B228743BC1FE9E6888E999BC0E4F615E36F9E|yhxD]-[gene|80FE6BDB00D79C9D2C821CFCE3F9D32AEEA65D9D|as-comK]-[gene|18C67A1723DD90E6344036D091A6F6A1AD148893|yhzC]
description
[pubmed|39470193]
regulation
induced under stress conditions ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]), requires read through at the terminator downstream of [gene|739B228743BC1FE9E6888E999BC0E4F615E36F9E|yhxD] [pubmed|39470193]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [pubmed|39470193], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
additional information
the transcript is cleaved between the [gene|80FE6BDB00D79C9D2C821CFCE3F9D32AEEA65D9D|as-comK] and [gene|18C67A1723DD90E6344036D091A6F6A1AD148893|yhzC] segments [pubmed|39470193]
genes
[gene|739B228743BC1FE9E6888E999BC0E4F615E36F9E|yhxD]
description
[Pubmed|8196543]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|15805528], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
Biological materials
Mutant
MGNA-A719 (yhxD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/719 NBRP B. subtilis, Japan]
BKE10430 ([gene|739B228743BC1FE9E6888E999BC0E4F615E36F9E|yhxD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAGCAACGCTCCTTTTC, downstream forward: _UP4_TAGCTTTATGAAAGGAGCTG
BKK10430 ([gene|739B228743BC1FE9E6888E999BC0E4F615E36F9E|yhxD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAGCAACGCTCCTTTTC, downstream forward: _UP4_TAGCTTTATGAAAGGAGCTG
References
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Time of last update: 2024-12-22 04:01:15
Author of last update: Jstuelk