besA

besA
168

Ferri-bacillibactin esterase

locus
BSU_32010
Molecular weight
35.34 kDa
pI
8.2
Protein length
Gene length
function
iron acquisition
product
ferri-bacillibactin esterase
essential
no
synonyms
besA, yuiI

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2819 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,292,490  3,293,359
The protein
Catalyzed reaction/ biological activity
catalyses ferri-bacillibactin hydrolysis leading to cytosolic iron release [pubmed|28283524]
Protein family
Esterase D family (single member, according to UniProt)
Structure
[PDB|2QM0] (from B. cereus, 46% identity)
[AF|O32102]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|71F490B2C3199734620724B51F8E3D7977C2D8D8|besA]
description
[Pubmed|12354229]
regulation
induced upon iron starvation ([protein|search|Fur]) [Pubmed|12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
Open in new tab

[gene|71F490B2C3199734620724B51F8E3D7977C2D8D8|besA]

2024-11-06 05:45:30

ghost

62

47ec4d76ad5e2c371270ca6764cc9b3380ed1856

1B6FA722267F9E9672F1D9EE321BADA35019E300

Biological materials
Mutant
MGNA-A650 (yuiI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/650 NBRP B. subtilis, Japan]
BKE32010 ([gene|71F490B2C3199734620724B51F8E3D7977C2D8D8|besA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCAGTACGACATTCCTC,  downstream forward: _UP4_TGAGACATACTCAGCCTTGC
BKK32010 ([gene|71F490B2C3199734620724B51F8E3D7977C2D8D8|besA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCAGTACGACATTCCTC,  downstream forward: _UP4_TGAGACATACTCAGCCTTGC
References
16889643,12354229,19673474,20817675,28283524

71F490B2C3199734620724B51F8E3D7977C2D8D8

Page visits: 4053

Time of last update: 2024-11-08 06:36:34

Author of last update: Jstuelk