thyA
168
thymidylate synthase A
locus
BSU_17680
Molecular weight
32.65 kDa
pI
5.5
function
biosynthesis of thymidine nucleotides
product
thymidylate synthase A
essential
no
ec
2.1.1.45
synonyms
thyA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0207 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,902,219 1,903,058
The protein
Catalyzed reaction/ biological activity
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP --> 7,8-dihydrofolate + dTMP (according to UniProt)
Protein family
thymidylate synthase family (with [protein|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB], according to UniProt)
Structure
[PDB|1B02] [pubmed|10091656]
[AF|P0CI79]
Paralogous protein(s)
[protein|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|6FE1D3C4D4DF86DE2D3D9A143A1DCFE120F13F5F|thyA]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE17680 ([gene|6FE1D3C4D4DF86DE2D3D9A143A1DCFE120F13F5F|thyA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACTATTCATATCCTTC, downstream forward: _UP4_TAATGCTGCCTTTTTATTGT
BKK17680 ([gene|6FE1D3C4D4DF86DE2D3D9A143A1DCFE120F13F5F|thyA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACTATTCATATCCTTC, downstream forward: _UP4_TAATGCTGCCTTTTTATTGT
References
Reviews
Original Publications
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Time of last update: 2024-12-26 08:40:52
Author of last update: Melvin.boenninger