yxeB
168
hydroxamate siderophore [wiki|ABC transporter] (only ferrioxamine) (binding protein)
locus
BSU_39610
Molecular weight
35.10 kDa
pI
5.53
function
siderophore uptake
product
hydroxamate siderophore [wiki|ABC transporter]
essential
no
synonyms
yxeB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0614 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,067,183 4,068,148
Phenotypes of a mutant
no growth with the xenosiderophore ferrioxamine E as single source of iron [Pubmed|23220087]
The protein
Protein family
[wiki|Bacterial solute-binding protein 8 family] (according to UniProt)
[wiki|Domains]
[wiki|Fe/B12 periplasmic-binding domain] (aa 58-316) (according to UniProt)
Structure
[PDB|4FNA] ([protein|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD] from Staphylococcus aureus, 35% identity) [pubmed|24606332]
[AF|P54941]
Paralogous protein(s)
[protein|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]
[wiki|Localization]
extracellular (signal peptide) [Pubmed|18957862]
membrane, lipid modification as retention signal [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|6F4F7A68701FAC3983AF447F11BC1EAB17D7B07B|yxeB]
description
[pubmed|12354229]
regulation
repressed unless the cells enter an iron starvation ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
MGNA-B706 (yxeB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1705 NBRP B. subtilis, Japan]
BKE39610 ([gene|6F4F7A68701FAC3983AF447F11BC1EAB17D7B07B|yxeB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAAGAACCCTCCCACTA, downstream forward: _UP4_TAAAAAAACGGCACAGTCAT
BKK39610 ([gene|6F4F7A68701FAC3983AF447F11BC1EAB17D7B07B|yxeB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAAGAACCCTCCCACTA, downstream forward: _UP4_TAAAAAAACGGCACAGTCAT
References
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Time of last update: 2024-12-30 15:23:10
Author of last update: Jstuelk