coaD
168
[metabolite|phosphopantetheine] adenylyltransferase
locus
BSU_15020
Molecular weight
18.04 kDa
pI
5.65
function
biosynthesis of [metabolite|coenzyme A]
product
[metabolite|phosphopantetheine] adenylyltransferase
essential
yes
ec
2.7.7.3
synonyms
ylbI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0669 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,570,078 1,570,563
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
[metabolite|ATP] + [metabolite|phosphopantetheine] + H+ --> 3'-[metabolite|dephospho-CoA] + [metabolite|diphosphate] [pubmed|39194188]
Protein family
bacterial coaD family (single member, according to UniProt)
Structure
[PDB|1O6B] (complex with ADP)
[AF|O34797]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[gene|FBD8F0EB241A35747E6398C9AA30D71D6D17CE99|ylbG]-[gene|65FA4B3738C2A5995F019099743C782ADD15C338|ylbH]-[gene|6DAAEF20B68139A732FDCDABD0C420A0C928D373|coaD]
description
[Pubmed|22383849]
genes
[gene|65FA4B3738C2A5995F019099743C782ADD15C338|ylbH]-[gene|6DAAEF20B68139A732FDCDABD0C420A0C928D373|coaD]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B360 (ylbI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1359 NBRP B. subtilis, Japan]
References
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Time of last update: 2024-12-30 10:15:22
Author of last update: Jstuelk