dapG
168
aspartokinase I (alpha and beta subunits)
locus
BSU_16760
Molecular weight
42.82 kDa
pI
5.71
function
biosynthesis of lysine and peptidoglycan
product
aspartokinase I (alpha and beta subunits)
essential
yes
ec
2.7.2.4
synonyms
dapG, lssD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0527 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,747,123 1,748,337
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
ATP + L-aspartate --> 4-phospho-L-aspartate + ADP (according to UniProt)
Protein family
aspartokinase family (with [protein|F7B947938FB40E54D89A719E9610C5A4AA400674|lysC] and [protein|548E92526BC00999031D6EDE43FE061CE0448AFC|thrD], according to UniProt)
[wiki|Domains]
[wiki|ACT domain] (aa 344-404) (according to UniProt)
Structure
[PDB|1SFT] (from ''Geobacillus stearothermophilus'', 57% identity) [Pubmed|9063881]
[AF|Q04795]
Effectors of protein activity
inhibited by diaminopimelic acid [Pubmed|2152900]
Paralogous protein(s)
[protein|F7B947938FB40E54D89A719E9610C5A4AA400674|lysC]
Expression and Regulation
Operons
genes
[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8098035], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]-[gene|4D93A13DB9DC55A49525BFF4FD589F4FF67D50E8|spoVFB]-[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|15699190,8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
References
Reviews
Original Publications
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Time of last update: 2024-10-12 13:50:23
Author of last update: Melvin.boenninger