ctaO
168
heme O synthase (minor enzyme)
locus
BSU_12080
Molecular weight
36.73 kDa
pI
10.12
function
heme biosynthesis
product
heme O synthase (minor enzyme)
essential
no
ec
null
synonyms
ctaO, yjdK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0109 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,279,514 1,280,503
The protein
Catalyzed reaction/ biological activity
(2E,6E)-farnesyl diphosphate + H2O + heme b --> diphosphate + Fe(II)-heme o (according to UniProt)
Protein family
UbiA prenyltransferase family (with [protein|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB], according to UniProt)
Structure
[AF|O31652]
Paralogous protein(s)
[protein|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|6CE139563BBD7C1C97AEC3AA3F88146C4EEA79E4|ctaO]
description
[Pubmed|21815947]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
additional information
the amount of the mRNA is substantially decreased upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
Biological materials
Mutant
MGNA-A273 (yjdK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/273 NBRP B. subtilis, Japan]
BKE12080 ([gene|6CE139563BBD7C1C97AEC3AA3F88146C4EEA79E4|ctaO]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12080 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTTTTGTTATCGTAAC, downstream forward: _UP4_TGATGCAAAAAGAGCCACAC
BKK12080 ([gene|6CE139563BBD7C1C97AEC3AA3F88146C4EEA79E4|ctaO]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12080 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTTTTGTTATCGTAAC, downstream forward: _UP4_TGATGCAAAAAGAGCCACAC
References
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Time of last update: 2024-10-06 12:31:32
Author of last update: Melvin.boenninger