tsaB
168
required for threonyl carbamoyl adenosine (t6A) modification of tRNAs that pair with ANN codons in mRNA
locus
BSU_05920
Molecular weight
25.10 kDa
pI
5.76
function
tRNA modification
product
tRNA modification enzyme
essential
yes
synonyms
tsaB, ydiC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1214 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
642,111 642,800
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
biosynthesis of the threonylcarbamoyladenosine (t6A) residue at position 37 of ANN-decoding tRNAs using L-threonylcarbamoyl-AMP ([protein|6CB350C335603D5F4434679F9D740BFECA738599|tsaB]-[protein|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD]-[protein|E15BB518649B2B9CD44CEBBB4FA481E55BCE823C|tsaE]) [Pubmed|23072323,21183954]
Protein family
KAE1 / TsaD family (with [protein|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD], according to UniProt)
Structure
[PDB|2A6A] (from ''Thermotoga maritima'', 24% identity) [Pubmed|20944216]
[AF|O05516]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|DE32F1DA1EA1164411E0605262381BD38A49656C|thiL]-[gene|E15BB518649B2B9CD44CEBBB4FA481E55BCE823C|tsaE]-[gene|6CB350C335603D5F4434679F9D740BFECA738599|tsaB]-[gene|C2283BDD806221A285A27F24F52F92F4D47F0C55|rimI]-[gene|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD]
description
[Pubmed|22383849]
References
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Time of last update: 2024-12-21 14:44:53
Author of last update: Jstuelk