tsaB

tsaB
168

required for threonyl carbamoyl adenosine (t6A) modification of tRNAs that pair with ANN codons in mRNA

locus
BSU_05920
Molecular weight
25.10 kDa
pI
5.76
Protein length
Gene length
function
tRNA modification
product
tRNA modification enzyme
essential
yes
synonyms
tsaB, ydiC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1214 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
642,111  642,800
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
biosynthesis of the threonylcarbamoyladenosine (t6A) residue at position 37 of ANN-decoding tRNAs using L-threonylcarbamoyl-AMP ([protein|6CB350C335603D5F4434679F9D740BFECA738599|tsaB]-[protein|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD]-[protein|E15BB518649B2B9CD44CEBBB4FA481E55BCE823C|tsaE]) [Pubmed|23072323,21183954]
Protein family
KAE1 / TsaD family (with [protein|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD], according to UniProt)
Structure
[PDB|2A6A] (from ''Thermotoga maritima'', 24% identity) [Pubmed|20944216]
[AF|O05516]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|DE32F1DA1EA1164411E0605262381BD38A49656C|thiL]-[gene|E15BB518649B2B9CD44CEBBB4FA481E55BCE823C|tsaE]-[gene|6CB350C335603D5F4434679F9D740BFECA738599|tsaB]-[gene|C2283BDD806221A285A27F24F52F92F4D47F0C55|rimI]-[gene|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD]
description
[Pubmed|22383849]
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[gene|DE32F1DA1EA1164411E0605262381BD38A49656C|thiL]→[gene|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD]

2024-09-25 07:52:22

ghost

109

45839886739c513a86015eb2db5091e043ecd558

F160E3DB3BAB4687DBF8F609242CE813EE9E1BF6

References
19376873,17005971,21285948,23072323,22383849,20944216,29741707,33524148

6CB350C335603D5F4434679F9D740BFECA738599

Page visits: 4202

Time of last update: 2024-10-04 12:56:32

Author of last update: Jstuelk