znuC
168
high-affinity [wiki|ABC transporter] for zinc ([metabolite|ATP]-binding protein)
locus
BSU_02860
Molecular weight
26.17 kDa
pI
8.2
function
zinc uptake
product
[wiki|ABC transporter] for zinc ([metabolite|ATP]-binding protein)
essential
no
ec
3.6.3.-
synonyms
znuC, ycdI, adcC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1121 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
309,347 310,042
Phenotypes of a mutant
reduced genetic competence, can be rescued by the addition of excess zinc [Pubmed|21813502]
reduced expression of the ''[gene|45F27C0789199626BA90D2C69E8F13525C911478|comFA]-[gene|D290247A43280532947B707F3AF388D7A7F404D3|comFB]-[gene|04D9D70C0BCFDCBD00B5156908C348135080A9C2|comFC]-[gene|049B1EBF64F0EBC04CE6D529C8EDB0B6B2184DF5|yvyF]-[gene|F03144BF8A187C8931938A21433431B8961E8EE7|flgM]-[gene|6F4CD36D4C1EE99EF7A503F44F53AEB8EFFEAB7F|flgN]-[gene|767ADBEF1B40CB3C74116CEA8CFB2FAF19C1FE7B|flgK]-[gene|82AB04023BCB57967C7501E6AEAC4BB593AA6480|flgL]'' operon [Pubmed|21813502]
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 4-230) (according to UniProt)
Structure
[PDB|4YMS] (from ''Caldanaerobacter subterraneus'', 31% identity) [Pubmed|25848002]
[AF|O34946]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|D33A144568CAF32FFE4A2A46BE67573DB66FC1A1|znuA]-[gene|6B5D4FD32CCE72C99B915B0F1EB4B8E8D42A04B3|znuC]-[gene|EE212953BC83BD6D69BF769D6E917F4F954BE1E2|znuB]
description
[Pubmed|9811636]
regulation
induced by zinc starvation ([protein|search|Zur]) [Pubmed|12426338]
regulatory mechanism
[protein|A0CD8CCB54AE9F10DE3C876FB47B9877C303862D|zur]: repression, in the presence of zinc [Pubmed|12426338], in [regulon|protein:A0CD8CCB54AE9F10DE3C876FB47B9877C303862D|zur regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|12426338], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-B981 (ycdI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1980 NBRP B. subtilis, Japan]
BKE02860 ([gene|6B5D4FD32CCE72C99B915B0F1EB4B8E8D42A04B3|znuC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTAATCTTCCTTTCTC, downstream forward: _UP4_GGATGGAAATGTTTGACTTG
BKK02860 ([gene|6B5D4FD32CCE72C99B915B0F1EB4B8E8D42A04B3|znuC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTAATCTTCCTTTCTC, downstream forward: _UP4_GGATGGAAATGTTTGACTTG
References
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Time of last update: 2024-12-30 18:44:11
Author of last update: Jstuelk