qdoI
168
Fe-containing quercetin 2,3-dioxygenase
locus
BSU_39980
Molecular weight
37.43 kDa
pI
5.56
function
resistance to plant product quercetin
product
Fe-containing quercetin 2,3-dioxygenase
essential
no
synonyms
qdoI, yxaG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1917 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,106,245 4,107,258
The protein
Catalyzed reaction/ biological activity
oxidation of the flavonol quercetin with dioxygen, cleaving the central heterocyclic ring and releasing CO
O2 + quercetin --> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO (according to UniProt)
Protein family
bicupin family
[wiki|Domains]
2 [wiki|cupin 2 domain]s (aa 55 ... 110, aa 226 ... 281)
[wiki|Cofactors]
Mn(II) (preferred), but also active with Fe(II) snd Co(II) [Pubmed|22084064]
Structure
[PDB|1Y3T] [Pubmed|15628860]
[PDB|2H0V]
[AF|P42106]
Expression and Regulation
Operons
genes
[gene|6A68EF7BF16FC2F2C7E068F52901EF2BFD6EBF8A|qdoI]-[gene|142444E1167BA7428EB95E4418C839ADF3E728B0|yxaH]
description
[Pubmed|10746760]
regulation
induced by flavonoids such as quercetin ([protein|search|QdoR], [protein|search|LmrA]) [Pubmed|17483215]
regulatory mechanism
[protein|52D560AA02F0849CB24460A496021560063B2E12|lmrA]: repression, [Pubmed|15317768], in [regulon|protein:52D560AA02F0849CB24460A496021560063B2E12|lmrA regulon]
[protein|47387014B5E89BF218BA94D8C2A570479B1EFD4E|qdoR]: repression, [Pubmed|17483215], in [regulon|protein:47387014B5E89BF218BA94D8C2A570479B1EFD4E|qdoR regulon]
additional information
major regulator: [protein|search|QdoR] [PubMed|17483215]
Biological materials
Mutant
MGNA-B684 (yxaG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1683 NBRP B. subtilis, Japan]
BKE39980 ([gene|6A68EF7BF16FC2F2C7E068F52901EF2BFD6EBF8A|qdoI]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTATCGCTTCCTCCAA, downstream forward: _UP4_TAAAGATGACAAGATTGTAA
BKK39980 ([gene|6A68EF7BF16FC2F2C7E068F52901EF2BFD6EBF8A|qdoI]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTATCGCTTCCTCCAA, downstream forward: _UP4_TAAAGATGACAAGATTGTAA
References
Reviews
Original Publications
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Time of last update: 2025-04-30 18:46:39
Author of last update: Melvin.boenninger