ykoG
168
two-component response regulator ([wiki|OmpR family])
locus
BSU_13250
Molecular weight
25.86 kDa
pI
5.11
function
unknown
product
two-component response regulator ([wiki|OmpR family])
essential
no
synonyms
ykoG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,391,953 1,392,639
The protein
Protein family
[wiki|OmpR family] of two-component response regulators
[wiki|Domains]
[wiki|Response regulatory domain] (aa 5-119) (according to UniProt)
Structure
[PDB|5ED4] (from Mycobacterium tuberculosis, 44% identity) [pubmed|27079268]
[AF|O34903]
Modification
phosphorylated by [protein|9E8A6AB3920BFBFDAAD1F2E4F333A32354ABB25B|ykoH] on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
Paralogous protein(s)
[protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ], [protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR], [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|6A37531896205A9B894C81AB0563C216C0B52CD7|ykoG]-[gene|9E8A6AB3920BFBFDAAD1F2E4F333A32354ABB25B|ykoH]-[gene|0678357183072D2716B913C07103CEBF65E60D14|ykoI]-[gene|348EAFC260435B3E0ED3CC7BC27EBA8DCFCBBEDC|ykoJ]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-A775 (ykoG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/775 NBRP B. subtilis, Japan]
BKE13250 ([gene|6A37531896205A9B894C81AB0563C216C0B52CD7|ykoG]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATTTGACCATCCTCTCC, downstream forward: _UP4_GGCTATGCCATTAAGGGGTA
BKK13250 ([gene|6A37531896205A9B894C81AB0563C216C0B52CD7|ykoG]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATTTGACCATCCTCTCC, downstream forward: _UP4_GGCTATGCCATTAAGGGGTA
References
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Time of last update: 2024-10-07 16:45:22
Author of last update: Melvin.boenninger