hisS
168
histidyl-tRNA synthetase
locus
BSU_27560
Molecular weight
47.97 kDa
pI
5.23
function
translation
product
histidyl-tRNA synthetase
essential
yes
ec
6.1.1.21
synonyms
hisS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0124 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,816,535 2,817,809
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-histidine + tRNAHis --> AMP + diphosphate + H+ + L-histidyl-tRNAHis (according to UniProt)
Protein family
[wiki|Class-II aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1H4V] (from ''Thermus thermophilus'', 43% identity, 61% similarity) [Pubmed|11399074]
[AF|O32039]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|69C7EF7E76821FF3D9E866838B24C3866CA9C189|hisS]-[gene|2B61D17950ADE0247B0CF4AE33548E15C0DDCD9B|aspS]
regulation
induced by histidine or aspartate limitation ([wiki|T-box]) [Pubmed|19258532]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: RNA switch, via tRNA controlled [wiki|RNA switch], in [regulon|other_regulator:T-box|T-box]
References
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Time of last update: 2024-12-20 13:40:24
Author of last update: Jstuelk