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exuR
168
repression of the hexuronate utilization operon ([gene|5A0C29C7E218701727523885D01A48D02266B421|uxaC]-[gene|59CD3E4C24326542D9C85BB6FE64FBF49869EB55|yjmB]-[gene|3AEA5D769B89E676C916FD8934D762B4C9A02AA2|yjmC]-[gene|CC55984E31C5698668CCCD4AC6E2210B2B41ACAB|yjmD]-[gene|A0A6D36BEC397345A1D17E6A7C34E1F612FD46C7|uxuA]-[gene|B886E504A767343042DE9BF4E23E6798D124A2CF|yjmF]-[gene|6D08E897DD697523FD0720704A25AD4472075B6C|exuT]-[gene|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]-[gene|A1C64447E0074B06C9210CC51680273FAAE703FA|uxaB]-[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA])
Molecular weight
37.22 kDa
function
regulation of hexuronate utilization
product
transcriptional repressor ([wiki|LacI family])
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
1,308,802 1,309,803
The protein
Protein family
[wiki|Domains]
[wiki|HTH lacI-type domain] (aa 2-56) (according to UniProt)
Structure
[PDB|2HSG] ([protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA], 32% identity) [pubmed|17500051]
[AF|Q9JMQ1]
Effectors of protein activity
galacturonate acts as the molecular inducer [Pubmed|9882655]
Expression and Regulation
Operons
genes
[gene|3AEA5D769B89E676C916FD8934D762B4C9A02AA2|yjmC]-[gene|CC55984E31C5698668CCCD4AC6E2210B2B41ACAB|yjmD]-[gene|A0A6D36BEC397345A1D17E6A7C34E1F612FD46C7|uxuA]-[gene|B886E504A767343042DE9BF4E23E6798D124A2CF|yjmF]-[gene|6D08E897DD697523FD0720704A25AD4472075B6C|exuT]-[gene|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]-[gene|A1C64447E0074B06C9210CC51680273FAAE703FA|uxaB]-[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]
description
[Pubmed|9882655]
regulation
induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]
regulatory mechanism
[protein|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]: repression, in the absence of inducer, in [regulon|protein:69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [pubmed|9882655] [pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9882655], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,9882655], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Open in new tab
[gene|3AEA5D769B89E676C916FD8934D762B4C9A02AA2|yjmC]→[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]
2024-10-06 08:05:53
ghost
72
e9b60dda83535baf9252c89c7130d2fdeb844e6f
417675688A3DB0A933113CA632D3321516D969A2
genes
[gene|5A0C29C7E218701727523885D01A48D02266B421|uxaC]-[gene|59CD3E4C24326542D9C85BB6FE64FBF49869EB55|yjmB]-[gene|3AEA5D769B89E676C916FD8934D762B4C9A02AA2|yjmC]-[gene|CC55984E31C5698668CCCD4AC6E2210B2B41ACAB|yjmD]-[gene|A0A6D36BEC397345A1D17E6A7C34E1F612FD46C7|uxuA]-[gene|B886E504A767343042DE9BF4E23E6798D124A2CF|yjmF]-[gene|6D08E897DD697523FD0720704A25AD4472075B6C|exuT]-[gene|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]-[gene|A1C64447E0074B06C9210CC51680273FAAE703FA|uxaB]-[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]
description
[Pubmed|9882655]
regulation
induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]
regulatory mechanism
[protein|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]: repression, in the absence of inducer, in [regulon|protein:69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [pubmed|9882655] [pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9882655], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab
[gene|5A0C29C7E218701727523885D01A48D02266B421|uxaC]→[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]
2024-10-09 18:29:25
ghost
75
0325999ea185bfaaf2dea87e1701479c52256033
A15F6E93B04DC8C4B59B7976DAC34CE9AC0B8E51
Biological materials
Mutant
MGNA-A372 (yjmH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/372 NBRP B. subtilis, Japan]
BKE12370 ([gene|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12370 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTAATTCCCTTCCTTAT, downstream forward: _UP4_TGATGTCCCGTTTTTCAGCG
BKK12370 ([gene|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12370 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTAATTCCCTTCCTTAT, downstream forward: _UP4_TGATGTCCCGTTTTTCAGCG
References
9579062,9882655,10666464,17500051