mrgA
168
iron storage protein, DNA-binding stress protein, forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing
locus
BSU_32990
Molecular weight
17.19 kDa
pI
4.6
function
iron storage,
product
mini-ferritin, DNA-binding stress protein
essential
no
synonyms
mrgA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0783 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,383,565 3,384,026
The protein
Catalyzed reaction/ biological activity
forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing
Protein family
dps family (with [protein|11D04B31B4BF223E276077EC16BBDA566694CBF6|dps], according to UniProt)
[wiki|Cofactors]
contains an iron-sulfur cluster
Structure
[PDB|2CHP] [pubmed|16893214]
[AF|P37960]
Paralogous protein(s)
[protein|11D04B31B4BF223E276077EC16BBDA566694CBF6|dps]
Expression and Regulation
Operons
genes
[gene|D945CAD7209CB94A7B9E23263476124B7E8853DD|yusZ]-[gene|68EFECAC6B771D7BDCCD7FD30511152EDEFCEE5B|mrgA]
description
[Pubmed|22383849]
genes
[gene|68EFECAC6B771D7BDCCD7FD30511152EDEFCEE5B|mrgA]
description
[Pubmed|8396117]
regulation
induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]
regulatory mechanism
[protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR]: repression, [Pubmed|11532148], in [regulon|protein:00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|14563870], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE32990 ([gene|68EFECAC6B771D7BDCCD7FD30511152EDEFCEE5B|mrgA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGATAACGTCCTCCTT, downstream forward: _UP4_TAACAAAAAAGCTGAACCTT
BKK32990 ([gene|68EFECAC6B771D7BDCCD7FD30511152EDEFCEE5B|mrgA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGATAACGTCCTCCTT, downstream forward: _UP4_TAACAAAAAAGCTGAACCTT
lacZ fusion
pGP3878 (kan, based on [wiki|pAC7]]), available in [wiki|Jörg Stülke]'s lab
GP4301 ([gene|68EFECAC6B771D7BDCCD7FD30511152EDEFCEE5B|mrgA]-lacZ::aphA3), available in [wiki|Jörg Stülke]'s lab
References
Reviews
Original Publications
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Time of last update: 2024-10-14 03:45:45
Author of last update: Dennis.wicke