ecsB

ecsB
168

[wiki|ABC transporter] ( membrane protein), mutation affects proteolysis by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP] (no processing of [protein|D6C2B8ABBBD1F9F2D36C34098D5B811A15C60D3B|rsgI] resulting in absence if [protein|3DEAC421B4B173C6BBC700E57790751B7AFDF319|sigI] activity)

locus
BSU_10050
Molecular weight
47.14 kDa
pI
10.18
Protein length
408 aaSequenceBlast
Gene length
1227 bpSequenceBlast
function
regulation of the secretion apparatus and of intra-membrane proteolysis
product
[wiki|ABC transporter] ( membrane protein)
essential
no
synonyms
ecsB, prsT, yhaC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4473 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,078,176  1,079,402
Phenotypes of a mutant
inactivation of ''[gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]'' reduces sporulation efficiency to 13.4% that of wild type cells [Pubmed|26735940]
no processing of [protein|4E720917045032E8B45CB8AF6E5C13AE0E48EE33|rsiW] and [protein|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL], impaired activity of [protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW] [pubmed|29343670]
a [gene|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] [gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB] mutant is not viable, due to lack of expression of [gene|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|lytE] [Pubmed|36265902]
The protein
Structure
[AF|P55340]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]-[gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]-[gene|6D07C98A82C8960133BC50E40EF5D56A21071316|ecsC]
description
[pubmed|22383849]
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[gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]->[gene|6D07C98A82C8960133BC50E40EF5D56A21071316|ecsC]

2024-12-30 16:21:50

Jstuelk

92

1ebc3613cb0a70a6101608dc452ef3e0cd005b40

D901973C8C05465263DFFB27B4F651A0C6D12528

additional information
the mRNA is very stable (> 15 min) [pubmed|12884008]
Biological materials
Mutant
BKE10050 ([gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10050 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CCGCGACTGCCAAATATCAA,  downstream forward: _UP4_CTGTGAACTGAAAAGAGGTA
BKK10050 ([gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10050 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CCGCGACTGCCAAATATCAA,  downstream forward: _UP4_CTGTGAACTGAAAAGAGGTA
References
Reviews
29343670
Original Publications
8581172,15175311,10092453,18599827,10027970,12884008,26735940,36265902,36815589,39397791

665BE3614B466067D64D1FB275ECDDE12CBFC9D4

Page visits: 2704

Time of last update: 2024-12-28 18:29:03

Author of last update: Jstuelk