ecsB
168
[wiki|ABC transporter] ( membrane protein), mutation affects proteolysis by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP] (no processing of [protein|D6C2B8ABBBD1F9F2D36C34098D5B811A15C60D3B|rsgI] resulting in absence if [protein|3DEAC421B4B173C6BBC700E57790751B7AFDF319|sigI] activity)
locus
BSU_10050
Molecular weight
47.14 kDa
pI
10.18
function
regulation of the secretion apparatus and of intra-membrane proteolysis
product
[wiki|ABC transporter] ( membrane protein)
essential
no
synonyms
ecsB, prsT, yhaC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4473 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,078,176 1,079,402
Phenotypes of a mutant
inactivation of ''[gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]'' reduces sporulation efficiency to 13.4% that of wild type cells [Pubmed|26735940]
no processing of [protein|4E720917045032E8B45CB8AF6E5C13AE0E48EE33|rsiW] and [protein|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL], impaired activity of [protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW] [pubmed|29343670]
a [gene|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] [gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB] mutant is not viable, due to lack of expression of [gene|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|lytE] [Pubmed|36265902]
The protein
Structure
[AF|P55340]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]-[gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]-[gene|6D07C98A82C8960133BC50E40EF5D56A21071316|ecsC]
description
[pubmed|22383849]
additional information
the mRNA is very stable (> 15 min) [pubmed|12884008]
Biological materials
Mutant
BKE10050 ([gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCGCGACTGCCAAATATCAA, downstream forward: _UP4_CTGTGAACTGAAAAGAGGTA
BKK10050 ([gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCGCGACTGCCAAATATCAA, downstream forward: _UP4_CTGTGAACTGAAAAGAGGTA
References
Reviews
Original Publications
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Time of last update: 2024-10-12 02:17:38
Author of last update: Jstuelk