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MntR and
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gmuR
168
transcriptional repressor (GntR family) of the [gene|00A4A90685CED4AD46829C45718CF26F1D62F5D3|gmuB]-[gene|44014896157718D3A6190DFDBD663C5CB9DA63FC|gmuA]-[gene|76324E0A6CAA8E1DD0B0C6FAE1CAB402231BF7CC|gmuC]-[gene|D8C81A8768E9C6B47B5E196B54DC2A3A8256E7E6|gmuD]-[gene|64CA75A26A08C534EC7ADFC4A6256F07F3D4BFB7|gmuR]-[gene|EB6DE119E6FB18413DB2C2B62B114FB787164F74|gmuE]-[gene|35225776F6044513D3E77DBBD6A7A8FE976F506A|gmuF]-[gene|289ACC9D13BBFAA5C083EE525ECCC32DB06E075F|gmuG] operon
Molecular weight
27.23 kDa
function
regulation of glucomannan utilization
product
transcriptional repressor (GntR family)
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
630,170 630,883
The protein
Protein family
[wiki|GntR family] of transcription factors
[wiki|Domains]
[wiki|HTH gntR-type domain] (aa 1-69) (according to UniProt)
Structure
[PDB|2WV0] (the structure of [protein|6D36D6360FE1CBFF5F64B2A6D1406405D6C6F7D5|nagR], 29% identity) [Pubmed|20047956]
[AF|O05509]
Paralogous protein(s)
[protein|6D36D6360FE1CBFF5F64B2A6D1406405D6C6F7D5|nagR], [protein|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|treR], [protein|F9E0C645BCCD9A299E951D0574321C1FACA8DE4C|ymfC], [protein|FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR], [protein|59EBB1812BA939110BC00ACE30057AB987E61B30|yydK], [protein|412A1DBBE7F87765DEBEEAAE02A047636A354D5E|frlR]
Expression and Regulation
Operons
genes
[gene|00A4A90685CED4AD46829C45718CF26F1D62F5D3|gmuB]-[gene|44014896157718D3A6190DFDBD663C5CB9DA63FC|gmuA]-[gene|76324E0A6CAA8E1DD0B0C6FAE1CAB402231BF7CC|gmuC]-[gene|D8C81A8768E9C6B47B5E196B54DC2A3A8256E7E6|gmuD]-[gene|64CA75A26A08C534EC7ADFC4A6256F07F3D4BFB7|gmuR]-[gene|EB6DE119E6FB18413DB2C2B62B114FB787164F74|gmuE]-[gene|35225776F6044513D3E77DBBD6A7A8FE976F506A|gmuF]-[gene|289ACC9D13BBFAA5C083EE525ECCC32DB06E075F|gmuG]
description
[Pubmed|18177310]
regulation
induced by cellobiose ([protein|64CA75A26A08C534EC7ADFC4A6256F07F3D4BFB7|gmuR]) [Pubmed|18177310]
regulatory mechanism
[protein|64CA75A26A08C534EC7ADFC4A6256F07F3D4BFB7|gmuR]: repression, [Pubmed|18177310], in [regulon|protein:64CA75A26A08C534EC7ADFC4A6256F07F3D4BFB7|gmuR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|18177310], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: activation, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|18177310], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[gene|00A4A90685CED4AD46829C45718CF26F1D62F5D3|gmuB]→[gene|289ACC9D13BBFAA5C083EE525ECCC32DB06E075F|gmuG]
2024-12-12 09:26:54
Jstuelk
96
1716709ba10a9af523abc0d89eb44ea784dd12d9
42FBC6CD7712CC913DB98C4B417CB4A13C8FAE20
Biological materials
Mutant
MGNA-C192 (ydhQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2190 NBRP B. subtilis, Japan]
BKE05850 ([gene|64CA75A26A08C534EC7ADFC4A6256F07F3D4BFB7|gmuR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGGTATCCTCCGGCAGC, downstream forward: _UP4_TGATTGCGGAGACAACAAGG
BKK05850 ([gene|64CA75A26A08C534EC7ADFC4A6256F07F3D4BFB7|gmuR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGGTATCCTCCGGCAGC, downstream forward: _UP4_TGATTGCGGAGACAACAAGG
References
18177310,10627040,18177310,20817675,20047956
