Explore the novel features of the upcoming release of in its beta version,
SubtiWiki v5! It features genomic conservation, interaction of proteins with metabolites, dedicated metabolite pages, and much more!
Check the pages for
MntR and
manganese!
yukB
168
membrane [protein|search|FtsK]/[protein|125325B485FBC60798EDA4B4BFB24C6FCBC4C513|spoIIIE]-like ATPase, part of the type VII protein secretion system [protein|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[protein|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[protein|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[protein|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[protein|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC]
Molecular weight
172.00 kDa
function
export of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]
product
membrane [protein|search|FtsK]/[protein|125325B485FBC60798EDA4B4BFB24C6FCBC4C513|spoIIIE]-like ATPase, part of the type VII protein secretion system
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
3,269,914 3,274,401
Phenotypes of a mutant
loss of secretion of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE] [Pubmed|24798022]
The protein
Catalyzed reaction/ biological activity
export of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE] [Pubmed|24828531,23861817]
secretion and delivery of [wiki|LXG domain] toxins [pubmed|34280190]
Protein family
EssC family (single member, according to UniProt)
[wiki|Domains]
2 [wiki|FtsK domain]s (aa 661-858, aa 993-1177) (according to UniProt)
Structure
[wiki|Localization]
membrane (according to SwissProt) [Pubmed|23861817]
cytoplasm (Homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]-[gene|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[gene|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[gene|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[gene|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC]-[gene|B258CA26B0EC2310475FCCD67F1F196857FC0004|yueD]
description
[Pubmed|22383849]
regulation
expressed in the stationary phase [Pubmed|23861817]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P, [Pubmed|23861817], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab
[gene|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]→[gene|B258CA26B0EC2310475FCCD67F1F196857FC0004|yueD]
2024-10-10 16:51:40
Jstuelk
112
BB0E1B9684F16E121BAA022EF986B0285FB41FA7
CDC40F8A7006CF56CF9A6155897E8BD27FFEC7AA
Biological materials
Mutant
MGNA-A625 (yukB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/625 NBRP B. subtilis, Japan]
BKE31875 ([gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31875 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATGGCGAACCCCCTTAC, downstream forward: _UP4_TCTGCTGAAAGGGAGAGTGC
BKK31875 ([gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31875 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATGGCGAACCCCCTTAC, downstream forward: _UP4_TCTGCTGAAAGGGAGAGTGC
References
Reviews
19155186,11973144,38957458 Original Publications
16479537,15576783,22383849,23861817,24798022,24696501,24979678,33782055,34280190,36154281