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yukB
168
membrane [protein|search|FtsK]/[protein|125325B485FBC60798EDA4B4BFB24C6FCBC4C513|spoIIIE]-like ATPase, part of the type VII protein secretion system [protein|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[protein|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[protein|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[protein|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[protein|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC]
Molecular weight
172.00 kDa
function
export of [protein|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA], [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE], [protein|75B0239578C92D4F3B298CBB077635BF5567C590|yxiB], [protein|2401A4E3E5E683472C51AB2F31BC4F54F672F32A|ywqH] [Pubmed|39436054,24828531,23861817,11973144]
product
membrane [protein|search|FtsK]/[protein|125325B485FBC60798EDA4B4BFB24C6FCBC4C513|spoIIIE]-like ATPase, part of the type VII protein secretion system
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
3,269,914 3,274,401
Phenotypes of a mutant
loss of secretion of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE] [Pubmed|24798022]
The protein
Catalyzed reaction/ biological activity
export of [protein|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA], [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE], [protein|75B0239578C92D4F3B298CBB077635BF5567C590|yxiB], [protein|2401A4E3E5E683472C51AB2F31BC4F54F672F32A|ywqH] [Pubmed|39436054,24828531,23861817,11973144]
secretion and delivery of [wiki|LXG domain] toxins [pubmed|34280190]
Protein family
EssC family (single member, according to UniProt)
[wiki|Domains]
2 [wiki|FtsK domain]s (aa 661-858, aa 993-1177) (according to UniProt)
Structure
[wiki|Localization]
membrane (according to SwissProt) [Pubmed|23861817]
cytoplasm (Homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]-[gene|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[gene|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[gene|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[gene|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC]-[gene|B258CA26B0EC2310475FCCD67F1F196857FC0004|yueD]
description
[Pubmed|22383849]
regulation
expressed in the stationary phase [Pubmed|23861817]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P, [Pubmed|23861817], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[gene|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]→[gene|B258CA26B0EC2310475FCCD67F1F196857FC0004|yueD]
2024-12-21 13:17:46
Jstuelk
120
BB0E1B9684F16E121BAA022EF986B0285FB41FA7
CDC40F8A7006CF56CF9A6155897E8BD27FFEC7AA
Biological materials
Mutant
MGNA-A625 (yukB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/625 NBRP B. subtilis, Japan]
BKE31875 ([gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31875 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATGGCGAACCCCCTTAC, downstream forward: _UP4_TCTGCTGAAAGGGAGAGTGC
BKK31875 ([gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31875 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAATGGCGAACCCCCTTAC, downstream forward: _UP4_TCTGCTGAAAGGGAGAGTGC
References
Reviews
19155186,11973144,38957458 Original Publications
16479537,15576783,22383849,23861817,24798022,24696501,24979678,33782055,34280190,36154281,39436054
