yirB
168
anti-adaptor protein, inhibits [protein|87124945A1CBF7990856FBEB9EAD25096DAC0868|spxH], responsible for stabilization of [protein|2C6386E9A63F410558D168798D077DF91590F454|spx] in response to cell wall stress
locus
BSU_33029
Molecular weight
6.60 kDa
pI
9.931
function
control of [protein|2C6386E9A63F410558D168798D077DF91590F454|spx] proteolysis
product
anti-adaptor protein
essential
no
synonyms
yirB, yuzO
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,387,781 3,387,945
The protein
Catalyzed reaction/ biological activity
prevention of the [protein|87124945A1CBF7990856FBEB9EAD25096DAC0868|spxH]-[protein|2C6386E9A63F410558D168798D077DF91590F454|spx] interaction [Pubmed|21378193]
Structure
[PDB|5BRQ] (from B. licheniformis, 29% identity) [pubmed|26894535]
[AF|O32302]
Expression and Regulation
Operons
genes
[gene|5EC57A51EF2DC48070615653B7A3C1007CFEE01D|yirB]
description
[pubmed|30001325]
regulation
induced by vancomycin ([protein|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]-P) [pubmed|30001325]
induced by cell wall stress ([protein|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]) [pubmed|30001325]
regulatory mechanism
[protein|1D6C340264B8A75727E202AD2E37053091C94013|yuxN]: repression, [pubmed|30001325], in [regulon|protein:1D6C340264B8A75727E202AD2E37053091C94013|yuxN regulon]
[protein|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]: activation, CssR-P acts as anti-repressor [pubmed|30001325], in [regulon|protein:A40CD2C23A19860342F440284302EFFDAC09E88A|cssR regulon]
Biological materials
Mutant
BKE33029 ([gene|5EC57A51EF2DC48070615653B7A3C1007CFEE01D|yirB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33029 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTAGATTCACCCTTTC, downstream forward: _UP4_TAAAAAAATAGACTGCAAAA
BKK33029 ([gene|5EC57A51EF2DC48070615653B7A3C1007CFEE01D|yirB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33029 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTAGATTCACCCTTTC, downstream forward: _UP4_TAAAAAAATAGACTGCAAAA
References
Reviews
Research papers
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Time of last update: 2024-10-15 14:39:04
Author of last update: Jstuelk