spoVE
168
SEDS family peptidoglycan glycosyltransferase, required for spore cortex peptidoglycan synthesis
locus
BSU_15210
Molecular weight
39.97 kDa
pI
9.85
function
spore cortex peptidoglycan synthesis
product
SEDS family peptidoglycan glycosyltransferase
essential
no
synonyms
spoVE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0772 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,590,317 1,591,417
The protein
Protein family
[wiki|SEDS proteins] (shape, elongation, division, and sporulation) [Pubmed|27525505]
SEDS family (with [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|ftsW] and [protein|B405B3C21B464F904BBB2AFD5DA21ADE45B4DD96|rodA], according to UniProt)
Structure
[PDB|6BAR] (from Thermus thermophilus,corresponds to aa 99... 357, 38% identity) [pubmed|29590088]
[AF|P07373]
Paralogous protein(s)
[protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|ftsW], [protein|B405B3C21B464F904BBB2AFD5DA21ADE45B4DD96|rodA]
[wiki|Localization]
integral membrane protein, forespore [Pubmed|17981970]
Expression and Regulation
Operons
genes
[gene|D48B7591467C493D2214D37AEA83643FE8C27BC6|murE]-[gene|4D3D4429E1F387BACB0D5A1084AA8DF179A16685|mraY]-[gene|0A9FF5A66F73464A780914A1424979CE753B3D9C|murD]-[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]-[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|1391053]
regulation
expressed during vegatative growth [Pubmed|1391053]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: repression, [Pubmed|15383836], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|8320223], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
genes
[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]
description
[Pubmed|1391053]
regulation
expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|1391053]
genes
[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]-[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|1391053]
regulation
expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|1391053]
additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
Biological materials
Mutant
BKE15210 ([gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCAATCGACACCCCAA, downstream forward: _UP4_TAACGAATGTATTTCCAAGC
BKK15210 ([gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCAATCGACACCCCAA, downstream forward: _UP4_TAACGAATGTATTTCCAAGC
References
Reviews
Original Publications
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Time of last update: 2024-12-20 09:18:12
Author of last update: Jstuelk