dnaC
168
replicative DNA helicase, part of the [wiki|replisome]
locus
BSU_40440
Molecular weight
50.44 kDa
pI
4.55
function
[category|SW.3.1.1|DNA replication]
product
replicative DNA helicase
essential
yes
ec
3.6.4.12
synonyms
dnaC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0305 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,157,471 4,158,835
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
stimulates [protein|F7B53E8AC92DAD15544C6208C2A5B41BABA73D6D|dnaG] primase activity [Pubmed|23563155]
ATP + H2O --> ADP + H+ + phosphate (according to UniProt)
Protein family
[wiki|helicase family] (according to UniProt)
[wiki|Domains]
SF4 helicase domain (aa 179-445) (according to UniProt)
Structure
[PDB|2R6A] (Geobacillus stearothermophilus), [PDB|2R6C], [PDB|2R6D], [PDB|2R6E] [pubmed|17947583]
[PDB|4M4W] (the [protein|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|dnaC]-[protein|AC1B507C6B1640E9BEA1F9F01628120F3680C976|dnaI]-[protein|F7B53E8AC92DAD15544C6208C2A5B41BABA73D6D|dnaG] complex) [Pubmed|24048025]
[AF|P37469]
[wiki|Localization]
Cytoplasm (Homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|dnaC]
description
[pubmed|22383849]
Biological materials
two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system ([wiki|BACTH]), available in [wiki|Fabian Commichau]'s lab
References
Reviews
Original Publications
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Time of last update: 2024-12-20 21:06:44
Author of last update: Jstuelk