ggt

ggt
168

gamma-glutamyltransferase

locus
BSU_18410
Molecular weight
64.01 kDa
pI
5.45
Protein length
587 aaSequenceBlast
Gene length
1764 bpSequenceBlast
function
degradation of poly-glutamate capsules
product
gamma-glutamyltransferase
essential
no
ec
2.3.2.2
synonyms
ggt, pac
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0405 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,004,677  2,006,440
The protein
Catalyzed reaction/ biological activity
α-amino acid + N-terminal (5-L-glutamyl)-[peptide] --> 5-L-glutamyl amino acid + N-terminal L-α-aminoacyl-[peptide] (according to UniProt)
glutathione + H2O --> L-cysteinylglycine + L-glutamate (according to UniProt)
S-substituted glutathione + H2O --> S-substitued L-cysteinylglycine + L-glutamate (according to UniProt)
Protein family
gamma-glutamyltransferase family (with [protein|F1DF59528E340A65A982BD7E6621DDA82C10B2B5|ywrD], according to UniProt)
Structure
[PDB|2V36]
[AF|P54422]
[wiki|Localization]
extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|5C31D968E3786858B025CE02CFAC48F61700031F|ggt]
description
[Pubmed|22383849]
regulation
strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]
additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
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[gene|5C31D968E3786858B025CE02CFAC48F61700031F|ggt]

2024-12-21 15:13:19

ghost

66

a43d94dd582f261584f02a2bbe87ef072613582c

6AD798C23482E70A48481DFCEFE25962BB8DA435

Biological materials
Mutant
BKE18410 ([gene|5C31D968E3786858B025CE02CFAC48F61700031F|ggt]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18410 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTCCCTCCTATATG,  downstream forward: _UP4_TAAATAAAAAACTGTACTCG
BKK18410 ([gene|5C31D968E3786858B025CE02CFAC48F61700031F|ggt]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18410 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTCCCTCCTATATG,  downstream forward: _UP4_TAAATAAAAAACTGTACTCG
References
Reviews
33177298,33897647
Original Publications
27095459,15583164,12892879,18957862,20088880,22383849,23335395,23033921,21513304,21987357,24279353,24531494,24719567,29685354,30377645,37099056,38240797

5C31D968E3786858B025CE02CFAC48F61700031F

Page visits: 4915

Time of last update: 2024-12-20 20:51:22

Author of last update: Jstuelk