ggt
168
gamma-glutamyltransferase
locus
BSU_18410
Molecular weight
64.01 kDa
pI
5.45
function
degradation of poly-glutamate capsules
product
gamma-glutamyltransferase
essential
no
ec
2.3.2.2
synonyms
ggt, pac
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0405 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,004,677 2,006,440
The protein
Catalyzed reaction/ biological activity
α-amino acid + N-terminal (5-L-glutamyl)-[peptide] --> 5-L-glutamyl amino acid + N-terminal L-α-aminoacyl-[peptide] (according to UniProt)
glutathione + H2O --> L-cysteinylglycine + L-glutamate (according to UniProt)
S-substituted glutathione + H2O --> S-substitued L-cysteinylglycine + L-glutamate (according to UniProt)
Protein family
gamma-glutamyltransferase family (with [protein|F1DF59528E340A65A982BD7E6621DDA82C10B2B5|ywrD], according to UniProt)
Structure
[PDB|2V36]
[AF|P54422]
[wiki|Localization]
extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|5C31D968E3786858B025CE02CFAC48F61700031F|ggt]
description
[Pubmed|22383849]
regulation
strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]
additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
Biological materials
Mutant
BKE18410 ([gene|5C31D968E3786858B025CE02CFAC48F61700031F|ggt]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTCCCTCCTATATG, downstream forward: _UP4_TAAATAAAAAACTGTACTCG
BKK18410 ([gene|5C31D968E3786858B025CE02CFAC48F61700031F|ggt]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTCCCTCCTATATG, downstream forward: _UP4_TAAATAAAAAACTGTACTCG
References
Reviews
Original Publications
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Time of last update: 2024-10-11 11:19:59
Author of last update: Jstuelk