cysE
168
serine O-acetyltransferase
locus
BSU_00930
Molecular weight
24.00 kDa
pI
9.49
function
biosynthesis of cysteine
product
serine O-acetyltransferase
essential
no
ec
2.3.1.30
synonyms
cysE, cysA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1045 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
112,800 113,453
Phenotypes of a mutant
poor growth [pubmed|28189581]
non-transformable [pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
acetyl-CoA + L-serine --> CoA + O-acetyl-L-serine (according to UniProt)
Protein family
[wiki|Transferase hexapeptide repeat family] (according to UniProt)
Structure
[PDB|1T3D] (from ''Escherichia coli'', 48% identity, 64% similarity) [Pubmed|15231846]
[AF|Q06750]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|132E91DB8C81CD8C4F5160B2C068B74DA10AE224|gltX]-[gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE]-[gene|E5826A99769E2FE45959A9D623D6467A8DDDEB81|cysS]-[gene|031FDF8443A8A4D5B042B7591EBE2E6C74F07702|mrnC]-[gene|8CB595F84D00D1262EB13E6CF47BE6F00EDE16A5|yacO]-[gene|172652156ABFE72D5BAAC22729CE17CA947538B5|yacP]
description
[Pubmed|7510287]
regulation
expression transiently increases in the forespore [Pubmed|22848659]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: RNA switch, overlaps a transcription terminator upstream of [gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE], in [regulon|other_regulator:T-box|T-box]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7510287], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE00930 ([gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATGCTTCCCCCCGTTTC, downstream forward: _UP4_AGAAAAGAAAGGATCAATCA
BKK00930 ([gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATGCTTCCCCCCGTTTC, downstream forward: _UP4_AGAAAAGAAAGGATCAATCA
References
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Time of last update: 2025-01-13 19:24:07
Author of last update: Melvin.boenninger