catR
168
[wiki|MarR family|MarR/DUF24 family] transcription repressor of the [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE] operon
locus
BSU_33680
Molecular weight
26.99 kDa
pI
9.89
function
resistance against oxidative and electrophile stress
product
[wiki|MarR family|MarR/DUF24 family] transcription repressor
essential
no
synonyms
catR, yvaP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1733 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,457,615 3,457,941
Phenotypes of a mutant
increased resistance to catechol and quinones [Pubmed|20639328]
The protein
Catalyzed reaction/ biological activity
[wiki|MarR family|MarR/DUF24 family] transcription repressor of the [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE] operon [Pubmed|20639328]
Protein family
[wiki|MarR family|MarR/DUF24 family]
[wiki|Domains]
[wiki|HTH hxlR-type domain] (aa 7-106) (according to UniProt)
Structure
[PDB|5HS7] ([protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB], 46% identity) [Pubmed|27531959]
[AF|O32238]
Modification
in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE]) [Pubmed|20639328]
Paralogous protein(s)
[protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]
Expression and Regulation
Operons
genes
[gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-A451 (yvaP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/451 NBRP B. subtilis, Japan]
BKE33680 ([gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTTTTCACCTCGTCTG, downstream forward: _UP4_TAATTGCTAAAATGGTTCTG
BKK33680 ([gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTTTTCACCTCGTCTG, downstream forward: _UP4_TAATTGCTAAAATGGTTCTG
labs
[wiki|Haike Antelmann],University of Greifswald, Germany
References
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Time of last update: 2025-03-14 17:56:20
Author of last update: Melvin.boenninger