rsbW
168
anti-[wiki|sigma factor] to [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB], protein serine kinase, phosphorylates [protein|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]
locus
BSU_04720
Molecular weight
17.85 kDa
pI
4.28
function
control of [protein|search|SigB ]activity
product
anti-[wiki|sigma factor], protein serine kinase
essential
no
synonyms
rsbW
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2172 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
522,414 522,896
The protein
Catalyzed reaction/ biological activity
phosphorylation of [protein|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]
negative regulator (by binding) of [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]
ATP + L-seryl-[protein] --> ADP + H+ + O-phospho-L-seryl-[protein] (according to UniProt)
ATP + L-threonyl-[protein] --> ADP + H+ + O-phospho-L-threonyl-[protein] (according to UniProt)
Protein family
anti-sigma-factor family (with [protein|C8B867758330355F44C63CC284DC7AA3061FB9F1|spoIIAB], according to UniProt)
Structure
[PDB|1TIL] ([protein|C8B867758330355F44C63CC284DC7AA3061FB9F1|spoIIAB], 32% identity) [pubmed|15236958]
[AF|P17904]
Expression and Regulation
Operons
genes
[gene|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]-[gene|841CE7FCA4E84445830CA18F9856F6F30014E3BB|rsbS]-[gene|ADC52A22950736A0435AEEEC43F7407878786A81|rsbT]-[gene|0B8381D2C724DAA724E4AFC67000F12AD112D13D|rsbU]-[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|8002610]
regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|20454630], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8002610], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
genes
[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|2170324]
regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
Biological materials
Mutant
BKE04720 ([gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE04720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCGATGTAATCAGCATTAT, downstream forward: _UP4_TATTTAAATGGGGAGCGAGT
BKK04720 ([gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK04720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCGATGTAATCAGCATTAT, downstream forward: _UP4_TATTTAAATGGGGAGCGAGT
labs
[wiki|Bill Haldenwang], San Antonio, USA
[wiki|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
References
Reviews
Original Publications
Page visits: 5195
Time of last update: 2024-10-11 15:35:45
Author of last update: Jstuelk