dapB
168
dihydrodipicolinate reductase (NADPH)
locus
BSU_22490
Molecular weight
29.34 kDa
pI
5.06
function
biosynthesis of lysine and peptidoglycan
product
dihydrodipicolinate reductase (NADPH)
essential
yes
ec
1.3.1.26
synonyms
dapB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0289 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,359,340 2,360,143
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD+ --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + NADH (according to UniProt)
(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP+ --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + NADPH (according to UniProt)
Protein family
DapB family (single member, according to UniProt)
[wiki|Cofactors]
NADP+
Structure
[PDB|1YL6] (from ''Mycobacterium tuberculosis'', 46% identity, 67% similarity) [Pubmed|20057050]
[AF|P42976]
Expression and Regulation
Operons
genes
[gene|A828298EA2A002538876FBA6113648AAD9C4C317|ypjD]-[gene|5AB90032031653A913E15B26B3E1AE246E95AABF|dapB]-[gene|341F198B2BD4261B20C00181D084A7C5E33E39B3|mgsA]-[gene|60367F0396612C8A6491FD92A73B30BED7215506|bshB1]-[gene|187C78441816FC74B0FCCE34997E8AEC0A80B114|bshA]-[gene|4C4FA59FF5D100E941EF470C0C54E85681ADC74F|cca]-[gene|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|birA]
description
[Pubmed|20308541]
regulation
induced by diamide stess (thiol depletion) ([protein|search|Spx]) [Pubmed|23894131]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|23894131], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|23894131], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
Operon and expression
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Time of last update: 2024-12-21 07:21:54
Author of last update: Melvin.boenninger