dapB

dapB
168

dihydrodipicolinate reductase (NADPH)

locus
BSU_22490
Molecular weight
29.34 kDa
pI
5.06
Protein length
Gene length
function
biosynthesis of lysine and peptidoglycan
product
dihydrodipicolinate reductase (NADPH)
essential
yes
ec
1.3.1.26
synonyms
dapB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0289 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,359,340  2,360,143
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD+ --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + NADH (according to UniProt)
(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP+ --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + NADPH (according to UniProt)
Protein family
DapB family (single member, according to UniProt)
[wiki|Cofactors]
NADP+
Structure
[PDB|1YL6] (from ''Mycobacterium tuberculosis'', 46% identity, 67% similarity) [Pubmed|20057050]
[AF|P42976]
Expression and Regulation
Operons
genes
[gene|A828298EA2A002538876FBA6113648AAD9C4C317|ypjD]-[gene|5AB90032031653A913E15B26B3E1AE246E95AABF|dapB]-[gene|341F198B2BD4261B20C00181D084A7C5E33E39B3|mgsA]-[gene|60367F0396612C8A6491FD92A73B30BED7215506|bshB1]-[gene|187C78441816FC74B0FCCE34997E8AEC0A80B114|bshA]-[gene|4C4FA59FF5D100E941EF470C0C54E85681ADC74F|cca]-[gene|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|birA]
description
[Pubmed|20308541]
regulation
induced by diamide stess (thiol depletion) ([protein|search|Spx]) [Pubmed|23894131]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|23894131], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|23894131], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|A828298EA2A002538876FBA6113648AAD9C4C317|ypjD]→[gene|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|birA]

2024-10-06 23:22:20

ghost

72

53bf67b167bd77fe013a5e22a2f6ddcbf0c547e2

73042872A92944881DD9D94DF293F1857E4735FB

References
Operon and expression
20308541,23894131

5AB90032031653A913E15B26B3E1AE246E95AABF

Page visits: 3670

Time of last update: 2024-10-07 14:20:20

Author of last update: Melvin.boenninger