comP
168
two-component sensor kinase, detects extracellular [protein|60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E|comX]
locus
BSU_31690
Molecular weight
89.13 kDa
pI
8
function
regulation of genetic competence and quorum sensing
product
two-component sensor kinase
essential
no
synonyms
comP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4585 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,253,529 3,255,838
Phenotypes of a mutant
the mutation suppresses the mucoid phenotype of ''[gene|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]'' or ''[gene|FE56753D061344B0F10A6523F49C5C7356AA40B6|motB]'' mutants due to loss of [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU] phosphorylation and concomitant reduced expression of the ''[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]'' operon [Pubmed|24296669]
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The protein
Catalyzed reaction/ biological activity
autophosphorylation
phosphorylation of [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] when bound to [protein|60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E|comX]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
eight transmembrane segments
[wiki|Histidine kinase domain] (aa 571-769) (according to UniProt)
Structure
[AF|Q99027]
Modification
autophosphorylation on a His residue
Effectors of protein activity
[protein|60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E|comX] (extracellular)
[wiki|Localization]
cell membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|FDACEF9DDC3BEA4EB013AE67BC47ADA532F00205|comQ]-[gene|60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E|comX]-[gene|5A00E233F0B5A0DAB18D2ECC55527F1911987F86|comP]-[gene|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]-[gene|015989AAB862E418C944AB35DA3605863F059CE9|yuxO]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2507523], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE31690 ([gene|5A00E233F0B5A0DAB18D2ECC55527F1911987F86|comP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATATTAATCCACCTATTA, downstream forward: _UP4_TAATGGATTTATAACGGAAA
BKK31690 ([gene|5A00E233F0B5A0DAB18D2ECC55527F1911987F86|comP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATATTAATCCACCTATTA, downstream forward: _UP4_TAATGGATTTATAACGGAAA
References
Reviews
Original Publications
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Time of last update: 2024-09-10 08:05:58
Author of last update: Melvin.boenninger