ytcA
168
similar to to UDP-sugar dehydrogenase
locus
BSU_30860
Molecular weight
46.67 kDa
pI
5.94
function
unknown
product
unknown
essential
no
synonyms
ytcA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1004 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,155,725 3,157,011
The protein
Catalyzed reaction/ biological activity
H2O + 2 NAD+ + UDP-α-D-glucose --> 3 H+ + 2 NADH + UDP-α-D-glucuronate (according to UniProt)
Protein family
UDP-glucose/GDP-mannose dehydrogenase family (with [protein|DF8CD0B3997A7A4CF4821A7D64E9898422FD17E0|tuaD] and [protein|45AFD434F5262BFBE4ED6DF3D18DAED61FF317D1|ugd], according to UniProt)
Structure
[PDB|4A7P] (from ''Sphingomonas elodea'', 39% identity)
[AF|O34862]
Paralogous protein(s)
[protein|DF8CD0B3997A7A4CF4821A7D64E9898422FD17E0|tuaD], [protein|45AFD434F5262BFBE4ED6DF3D18DAED61FF317D1|ugd]
Expression and Regulation
Operons
genes
[gene|59024C05AA0106719C81E45E3B060A6F710B2690|ytcA]-[gene|A51B5F9F86D2F7B690712B9EC181B1C07B312E02|ytcB]-[gene|6911DFB27F6A23F3775DAC5C289EFA163FBD1E56|ytcC]
description
[Pubmed|22383849]
regulation
expressed late during sporulation in the mother cell ([protein|6FAD8804AA32B84819DDE57C0AF63F208FB9FFD1|sigKC], [wiki|GerE]) [Pubmed|26577401,15699190,12480901]
regulatory mechanism
[protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]: repression, [Pubmed|26577401], in [regulon|protein:19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE regulon]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|22383849,15699190,12480901], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Biological materials
Mutant
MGNA-A280 (ytcA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/280 NBRP B. subtilis, Japan]
BKE30860 ([gene|59024C05AA0106719C81E45E3B060A6F710B2690|ytcA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCACCTGAGCTCCTTTAC, downstream forward: _UP4_ATCTGTACGGGAGTTGGCCG
BKK30860 ([gene|59024C05AA0106719C81E45E3B060A6F710B2690|ytcA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCACCTGAGCTCCTTTAC, downstream forward: _UP4_ATCTGTACGGGAGTTGGCCG
References
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Time of last update: 2024-10-11 20:52:25
Author of last update: Melvin.boenninger