fisB
168
membrane fission protein, mediates membrane fission during sporulation
locus
BSU_32350
Molecular weight
27.76 kDa
pI
9.53
function
release of the forespore into the mother cell cytoplasm
product
membrane fission protein
essential
no
ec
null
synonyms
fisB, yunB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5875 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,322,463 3,323,227
Phenotypes of a mutant
reduced sporulation efficiency (12 - 15%) [Pubmed|23388828]
The protein
Catalyzed reaction/ biological activity
mediates membrane fission during [wiki|sporulation] [Pubmed|23388828]
binds cardiolipin [Pubmed|23388828]
Structure
[AF|O32131]
[wiki|Localization]
cell membrane [Pubmed|23388828]
forms dynamic foci which become immobilized at the site of membrane fission [Pubmed|34185788,23388828]
Expression and Regulation
Operons
genes
[gene|588A4131772691A0402AD56B49D5C55D8BD46DFF|fisB]
description
[Pubmed|12662922]
regulation
expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|15699190,12662922]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,12662922], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Biological materials
Mutant
MGNA-A978 (yunB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/978 NBRP B. subtilis, Japan]
BKE32350 ([gene|588A4131772691A0402AD56B49D5C55D8BD46DFF|fisB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32350 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGAAAATCCCCCCTTACA, downstream forward: _UP4_TAAGCCGCCTGTTGAAGAGG
BKK32350 ([gene|588A4131772691A0402AD56B49D5C55D8BD46DFF|fisB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32350 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGAAAATCCCCCCTTACA, downstream forward: _UP4_TAAGCCGCCTGTTGAAGAGG
References
Reviews
Original Publications
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Time of last update: 2024-12-19 11:41:00
Author of last update: Jstuelk