comC
168
late competence gene required for processing and translocation of [protein|19D76B80386F825109C5FB4A34881D5D20F366DB|comGC], [protein|D323AEF5AFB4FD2A074ABAB76A39BE26A4C6436F|comGD], [protein|FF4DB7FDCEB440064E11E65CB0DBFB93FC785CF0|comGE] and [protein|89442BFDFBFF264D0C7F12DEA6F8130C55D1F3F8|comGG]
locus
BSU_28070
Molecular weight
26.37 kDa
pI
9.84
function
genetic competence
product
processing protease
essential
no
ec
null
synonyms
comC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1989 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,864,426 2,865,172
The protein
Catalyzed reaction/ biological activity
processing and translocation of [protein|19D76B80386F825109C5FB4A34881D5D20F366DB|comGC], [protein|D323AEF5AFB4FD2A074ABAB76A39BE26A4C6436F|comGD], [protein|FF4DB7FDCEB440064E11E65CB0DBFB93FC785CF0|comGE] and [protein|89442BFDFBFF264D0C7F12DEA6F8130C55D1F3F8|comGG] [Pubmed|9723928]
Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to UniProt)
Protein family
peptidase A24 family (single member, according to UniProt)
Structure
[AF|P15378]
[wiki|Localization]
integral membrane protein [Pubmed|24164455]
Expression and Regulation
Operons
genes
[gene|57FDE2ABB5E9773717C23D727FD6CDA5D8CC3E36|comC]
description
[Pubmed|1694528]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, [Pubmed|8196543], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1694528], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE28070 ([gene|57FDE2ABB5E9773717C23D727FD6CDA5D8CC3E36|comC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28070 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
BKK28070 ([gene|57FDE2ABB5E9773717C23D727FD6CDA5D8CC3E36|comC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28070 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
References
Reviews
Original Publications
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Time of last update: 2024-12-30 20:19:07
Author of last update: Jstuelk