rnpB
168
RNA component of RNase P
locus
BSU_misc_RNA_35
function
cleavage of precursor sequences from the 5 ends of pre-tRNAs
product
RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)
essential
yes
synonyms
rnpB, rnaP
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
Gene
Phenotypes of a mutant
essential [Pubmed|23109554]
RNA
Catalyzed reaction/ biological activity
processing of tRNAs
Effectors of RNA activity
[protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM] [pubmed|38050972]
additional information
KD ([protein|594F2D36BE71A45303A33AA2A2931F56F0A969ED|rnpA]-[protein|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] interaction): 40 nM [pubmed|15337847]
KD ([protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM]-[protein|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] interaction): 460 pM [pubmed|38050972]
The protein
Structure
[PDB|3DHS] catalytic domain of Geobacillus stearothermophilus RNase P RNA [pubmed|19095619]
[PDB|3Q1R] (complex of [protein|594F2D36BE71A45303A33AA2A2931F56F0A969ED|rnpA] with [protein|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] and [gene|3B6620F44EC08BA9B02FE9359A5F74C6CAE6D4FB|trnA-Ile], from ''Thermotoga maritima'') [Pubmed|21076397]
Expression and Regulation
Operons
genes
[gene|C22F7704DC9D36D96FE089ADCEA546D7A3FB3739|gpsB]-[gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB]-[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]
description
[Pubmed|22383849]
genes
[gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB]-[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]
description
[Pubmed|22383849]
labs
[wiki|Carol Fierke], University of Michigan, Ann Arbor, USA [https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=fierke homepage]
[wiki|Roland Hartmann], Marburg University, Germany [http://www.pharmazie.uni-marburg.de/pharmchem/akhartmann/ag_hartmann.htm homepage]
References
Reviews
Original Publications
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Time of last update: 2024-10-13 04:35:27
Author of last update: Jstuelk