tuaA/2
168
lipid carrier sugar transferase, disrupted pseudogene in B. subtilis 168
locus
BSU_35610
function
biosynthesis of teichuronic acid
product
lipid carrier sugar transferase
essential
no
synonyms
tuaA\/2, yvhA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,658,407 → 3,658,892
The protein
Catalyzed reaction/ biological activity
di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-α-D-galactosamine --> N-acetyl-α-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP (according to UniProt)
Protein family
Bacterial sugar transferase family (with [protein|D67665412B78B56752B460219445E4BEF52C3A1A|epsL], according to UniProt)
Structure
[PDB|5W7L] (from Campylobacter concisus, 41% identity)
Paralogous protein(s)
[protein|D67665412B78B56752B460219445E4BEF52C3A1A|epsL]
Expression and Regulation
Operons
genes
[gene|5790E3DB39F31017B557C2D3F428C0348A461DA6|tuaA/2]-[gene|4AC72C556ED02A7DE4E1E8D69A0FC926359ACE28|tuaA/1]-[gene|54F96DE549F78E6C1580949A21C84B27AF26C4C6|tuaB]-[gene|873EE7A8C9BBFC6E96B0957B450BA665E3C9222D|tuaC]-[gene|DF8CD0B3997A7A4CF4821A7D64E9898422FD17E0|tuaD]-[gene|B89FA71C2924CC0690224AFBFA06DB0FF0D97C0A|tuaE]-[gene|6F0FA23892BB1829174F66C464149DB428A8DE18|tuaF]-[gene|6E4F2BA67FF58085D462F6A6FB6497BDF600FCF6|tuaG]-[gene|737B37DA0DA1642AD5C4A824228BFED55FF0652A|tuaH]
description
[Pubmed|10048024]
regulation
expressed during [wiki|sporulation] in the forespore ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]) [Pubmed|16497325,15699190]
regulatory mechanism
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|9611818,10627039], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|10048024], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325,15699190], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
Biological materials
Mutant
BKE35610 (Δ[gene|5790E3DB39F31017B557C2D3F428C0348A461DA6|tuaA/2]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGACACACACCTCACGA, downstream forward: _UP4_GAGATTCCAGGCTTTACACA
BKK35610 (Δ[gene|5790E3DB39F31017B557C2D3F428C0348A461DA6|tuaA/2]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGACACACACCTCACGA, downstream forward: _UP4_GAGATTCCAGGCTTTACACA
References
Page visits: 2725
Time of last update: 2024-12-18 14:08:37
Author of last update: Melvin.boenninger