feuB
168
[wiki|ABC transporter ]for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
locus
BSU_01620
Molecular weight
35.74 kDa
pI
9.54
function
[wiki|acquisition of iron]
product
[wiki|ABC transporter ]for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
essential
no
synonyms
feuB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0609 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
181,347 182,351
Phenotypes of a mutant
severe growth inhibition upon addition of subinhibitory concentrations of mirubactin C [pubmed|36312962]
The protein
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|FecCD subfamily] (according to UniProt)
Structure
[PDB|4G1U] (heme transporter from Yersinia pestis, 33% identity) [pubmed|23142986]
[AF|P40410]
Paralogous protein(s)
[protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD], [protein|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]-[gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]-[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]-[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA]
description
[Pubmed|12354229]
regulation
expression during spore [wiki|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [pubmed|29133393]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
[protein|EB28A65CECE994DF2DF486DEACF40F2533703DB0|btr]: activation, in the presence of the co-activators bacillibactin or enterobactin [Pubmed|17725565], in [regulon|protein:EB28A65CECE994DF2DF486DEACF40F2533703DB0|btr regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|17725565], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the presence of an iron-responsive element bound by [wiki|CitB] between ''[wiki|feuA]'' and ''[wiki|feuB]'' suggests iron-dependent regulation by [wiki|CitB] [Pubmed|10468622]
Other regulations
[protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|citB]: translation control
Biological materials
Mutant
BKE01620 ([gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE01620 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATACATACAAAAACCTACTC, downstream forward: _UP4_ATTAAACGAAAAGGAGGGGA
BKK01620 ([gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK01620 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATACATACAAAAACCTACTC, downstream forward: _UP4_ATTAAACGAAAAGGAGGGGA
References
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Time of last update: 2024-12-21 10:21:45
Author of last update: Jstuelk