fecC
168
iron/ citrate [wiki|ABC transporter] (binding protein)
locus
BSU_07520
Molecular weight
34.87 kDa
pI
7.88
function
iron uptake
product
iron/ citrate [wiki|ABC transporter] (binding protein)
essential
no
synonyms
fecC, yfmC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4594 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
825,787 826,734
Phenotypes of a mutant
poor growth with the Fe(III)-dicitrate as single source of iron [Pubmed|23220087]
The protein
Protein family
[wiki|Bacterial solute-binding protein 8 family] (according to UniProt)
[wiki|Domains]
[wiki|Fe/B12 periplasmic-binding domain] (aa 60-315) (according to UniProt)
Structure
[PDB|3EIW] (from ''Staphylococcus aureus'', the [protein|569510093E5B69A0368205920A21A81CADF030E9|fecC]-[protein|1469148C83B1704E721652203EA31F0E2C33FDC6|yhfQ] complex, 46% identity) [Pubmed|19400778]
[AF|O34348]
Paralogous protein(s)
[protein|1469148C83B1704E721652203EA31F0E2C33FDC6|yhfQ]
[wiki|Localization]
associated to the membrane (via [protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[protein|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]) [Pubmed|10092453,18763711]
extracellular (signal peptide) [Pubmed|18957862], lipid modification as retention signal
Expression and Regulation
Operons
genes
[gene|13FEC673232C5946C6EA7E9DD3AA6AA1A57269E1|yfmB]-[gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]
description
[Pubmed|22383849]
regulation
induced upon iron starvation ([protein|search|Fur]) [Pubmed|16672620,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [Pubmed|16672620,12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
genes
[gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]-[gene|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[gene|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]-[gene|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF]
description
[Pubmed|16672620]
regulation
immediately induced upon iron starvation (first wave to allow iron uptake) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,16672620,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [Pubmed|16672620,12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
genes
[gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]
description
[Pubmed|22383849]
regulation
induced upon iron starvation ([protein|search|Fur]) [Pubmed|16672620,12354229]
Biological materials
Mutant
MGNA-C246 (yfmC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2244 NBRP B. subtilis, Japan]
BKE07520 ([gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07520 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCATTCTTCCTTTTTT, downstream forward: _UP4_TAGGACAAATGAGAAGCGAG
BKK07520 ([gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07520 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCATTCTTCCTTTTTT, downstream forward: _UP4_TAGGACAAATGAGAAGCGAG
References
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Time of last update: 2024-12-19 21:41:02
Author of last update: Jstuelk