asd

asd
168

aspartate-semialdehyde dehydrogenase

locus
BSU_16750
Molecular weight
37.69 kDa
pI
4.97
Protein length
346 aaSequenceBlast
Gene length
1041 bpSequenceBlast
function
biosynthesis of threonine, lysine, dipicolic acid, peptidoglycan
product
aspartate-semialdehyde dehydrogenase
essential
yes
ec
1.2.1.11
synonyms
asd
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0136 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,745,991  1,747,031
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
L-aspartate 4-semialdehyde + NADP+ + phosphate --> 4-phospho-L-aspartate + H+ + NADPH (according to UniProt)
Protein family
aspartate-semialdehyde dehydrogenase family (single member, according to UniProt)
Structure
[PDB|2GYY] (from ''Streptococcus pneumoniae'', 52% identity, 65% similarity) [Pubmed|16895909]
[AF|Q04797]
Modification
phosphorylation on Ser-98 AND Tyr-146 [Pubmed|17218307]
Expression and Regulation
Operons
genes
[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8098035], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]→[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]

2024-12-04 00:00:00

ghost

90

26b99709bb2d46d49ca998bee33208e722bad3f7

5716FEABC6E16C3675FEA484CEBA95D8F93F13D1

genes
[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]-[gene|4D93A13DB9DC55A49525BFF4FD589F4FF67D50E8|spoVFB]-[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|15699190,8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Open in new tab

[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]→[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]

2024-12-01 13:42:39

ghost

101

9f1758bf801d23548827e9d03f6ca9d0c2e6746d

C373CB045AB9232B86B60761B90C3510E98A06A8

References
8345520,15699190,8098035,17218307

564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18

Page visits: 3841

Time of last update: 2024-12-04 15:22:14

Author of last update: Melvin.boenninger