pksC

pksC
168

bacillaene synthase trans-acting acyltransferase

Locus
BSU_17100
Molecular weight
32.31 kDa
Isoelectric point
5.33
Protein length
288 aaSequenceBlast
Gene length
867 bpSequenceBlast
Function
polyketide (bacillaene) synthesis
Product
bacillaene synthase trans-acting acyltransferase
Essential
no
Synonyms
pksC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0331 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,783,763  1,784,629
The protein
Catalyzed reaction/ biological activity
holo-[ACP] + malonyl-CoA --> CoA + malonyl-[ACP] (according to UniProt)
Protein family
fabD family (with FabD and PksE, according to UniProt)
Structure
5DZ6 (PDB)
O34825 (AlphaFold)
Expression and Regulation
Operons
Genes
pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
Description
PubMed
Regulation
expressed during the transition from growth to stationary phase (AbrB, CodY) PubMed
heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
CodY: activation, PubMed, in codY regulon
Additional information
this is a very large operon comprising about 75 kb
Open in new tab

pksC→pksR

2025-03-17 18:36:51

Jstuelk

162

74BF817D9000509D225BBBCAC6C8A0A9EABEB843

1475C94AAA2C10C6BE3CA0873EFBD171EC2E2513

Genes
pksB-pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
Description
PubMed
Open in new tab

pksB→pksR

2025-03-17 03:33:23

Jstuelk

136

c851e07b7201353cf026d8929ea66cff6bbb92e2

D95CF77A7673AA84CC653095A1FB017D490049D6

Biological materials
Mutant
MGNA-A016 (pksC::erm), available at the NBRP B. subtilis, Japan
BKE17100 (pksC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCTCTCAAAGCCACCCT,  downstream forward: _UP4_TAAAGCATTTGCCCCTATGG
BKK17100 (pksC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCTCTCAAAGCCACCCT,  downstream forward: _UP4_TAAAGCATTTGCCCCTATGG
References
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55C821F68B2E5F9F45CC2B2C9494D48D5C33266A

Page visits: 4912

Time of last update: 2025-03-17 17:47:43

Author of last update: Jstuelk