yacD
168
putative peptidyl-prolyl cis-trans isomerase, similar to secretion protein [protein|6EE13E61A218A6D52BAC83A1145B0B96961CE289|prsA]
locus
BSU_00720
Molecular weight
33.94 kDa
pI
4.95
function
unknown
product
unknown
essential
no
synonyms
yacD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0760 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
80,802 81,695
The protein
Catalyzed reaction/ biological activity
[protein]-peptidylproline (ω=180) --> [protein]-peptidylproline (ω=0) (according to UniProt)
peptidyl-prolyl cis-trans isomerase activity (according to UniProt)
[wiki|Domains]
PpiC domain (aa 154-247) (according to UniProt)
Structure
[PDB|5EZ1] (from Helicobacter pylori, 26% identity) [pubmed|26850168]
[AF|P37566]
[wiki|Localization]
extracellular (with signal peptide) (according to UniProt)
Expression and Regulation
Operons
genes
[gene|9B8EAD4EDDA97526D4462F6F3205F81FECD039DE|coaX]-[gene|D579A7E4D8C3DEE4F85586C5F721CAD5FE2BCA75|yacC]-[gene|548926987569033AA0C40610B8E80FB2BB8E1E3A|yacD]-[gene|D1FC976597E5583E40A4ED7234FBCA743AB01354|cysK]
description
[Pubmed|22383849]
regulation
induced by heat stress ([protein|2C6386E9A63F410558D168798D077DF91590F454|spx]) [pubmed|30480837]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [pubmed|30480837], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
Biological materials
Mutant
MGNA-B925 (yacD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1924 NBRP B. subtilis, Japan]
BKE00720 ([gene|548926987569033AA0C40610B8E80FB2BB8E1E3A|yacD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCTGCTTTCAGCCCCT, downstream forward: _UP4_TGATTGACAAAAAATTTTGA
BKK00720 ([gene|548926987569033AA0C40610B8E80FB2BB8E1E3A|yacD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCTGCTTTCAGCCCCT, downstream forward: _UP4_TGATTGACAAAAAATTTTGA
References
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Time of last update: 2024-12-30 08:53:20
Author of last update: Jstuelk