nupC
168
pyrimidine nucleoside transport protein
locus
BSU_39410
Molecular weight
42.37 kDa
pI
9.32
function
pyrimidine uptake
product
pyrimidine nucleoside transport protein
essential
no
synonyms
nupC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1972 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,050,340 4,051,521
The protein
Protein family
concentrative nucleoside transporter (CNT) (TC 2.A.41) family (with [protein|7D4CF2FF4108D3AE170C1EE3C7D494EAD46699C6|yutK] and [protein|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG], according to UniProt)
Structure
[PDB|3TIJ] (from Vibrio cholerae, 33% identity) [pubmed|22407322]
[AF|P39141]
[wiki|Localization]
membrane protein [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|81CD1F97E887549F7FB742FCEF38B86B84383F5D|dra]-[gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]-[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp]
description
[Pubmed|8550462]
regulation
induced by deoxynucleotides ([protein|search|DeoR]) [Pubmed|8550462]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]: repression, [Pubmed|8550462], in [regulon|protein:E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550462], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE39410 ([gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTGTTTCTCCTTTAT, downstream forward: _UP4_TGAACTTAATCGAAAAGGAT
BKK39410 ([gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTGTTTCTCCTTTAT, downstream forward: _UP4_TGAACTTAATCGAAAAGGAT
References
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Time of last update: 2024-12-30 10:25:34
Author of last update: Melvin.boenninger