hmoB

hmoB
168

heme monooxygenase

locus
BSU_10100
Molecular weight
18.68 kDa
pI
5.22
Protein length
Gene length
function
degradation of heme, acquisition of iron
product
heme monooxygenase
essential
no
ec
null
synonyms
hmoB, yixC, yhgC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2329 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,083,229  1,083,729
The protein
Catalyzed reaction/ biological activity
binds hemin ''in vitro'' with ~1:1 stoichiometry and degrade hemin in the presence of an electron donor [Pubmed|21873409]
heme b + 3 O2 + 3 reduced [NADPH—hemoprotein reductase] --> biliverdin IXα + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH—hemoprotein reductase] (according to UniProt)
Protein family
antibiotic biosynthesis monooxygenase family (with [protein|A4E1A1FA886980C863919DA011AC1EEDDBD74967|hmoA], according to UniProt)
[wiki|Domains]
[wiki|ABM domain] (aa 66-153) (according to UniProt)
Structure
[PDB|3TVZ] [Pubmed|22531134]
[AF|P38049]
Expression and Regulation
Operons
genes
[gene|4EE1809AC405170A78F6F8C8C02EEF5CC54DE076|hmoB]
description
[Pubmed|8335642]
regulation
constitutively expressed [Pubmed|21873409]
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[gene|4EE1809AC405170A78F6F8C8C02EEF5CC54DE076|hmoB]

2024-12-20 22:45:10

ghost

58

c8fea6cc81de05b03b762c84ff4989bd6c0a501d

8430CDF0C668E2DAE1761DCE095CA1D847DB10F2

Biological materials
Mutant
MGNA-B503 (yhgC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1502 NBRP B. subtilis, Japan]
BKE10100 ([gene|4EE1809AC405170A78F6F8C8C02EEF5CC54DE076|hmoB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10100 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCAGCCACCTCCTGCT,  downstream forward: _UP4_TAGCTGCCGGCATGTCCGGC
BKK10100 ([gene|4EE1809AC405170A78F6F8C8C02EEF5CC54DE076|hmoB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10100 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCAGCCACCTCCTGCT,  downstream forward: _UP4_TAGCTGCCGGCATGTCCGGC
References
8335642,22531134,24582752,21873409,37198628

4EE1809AC405170A78F6F8C8C02EEF5CC54DE076

Page visits: 4278

Time of last update: 2024-12-21 19:19:00

Author of last update: Jstuelk