melC
168
[wiki|ABC transporter] for melibiose and raffinose (permease)
locus
BSU_30290
Molecular weight
30.22 kDa
pI
9.85
function
uptake of melibiose and raffinose
product
sugar [wiki|ABC transporter]
essential
no
synonyms
melC, amyC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0395 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,100,031 3,100,861
The protein
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|Domains]
[wiki|ABC transmembrane type-1 domain] (aa 69-261) (according to UniProt)
Structure
[PDB|4TQU] (from Sphingomonas sp., 26% identity) [pubmed|26235029]
[AF|O34518]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|C3D7C64AD0E58BF326257E23136466A237138B50|melE]-[gene|05BFEA711D82395A55B505E5A38286BE2F570350|melD]-[gene|4E766839240C8F7D56D87DF9E7B99350A83B5FF7|melC]-[gene|CDE9EF9CFB799794D525F12DEC8C4190C6298575|melA]
description
[Pubmed|22383849]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|22900538]
genes
[gene|58276E6FEF9388BBC7FB79BB5A3A1EF3C3DA5BD5|melR]-[gene|C3D7C64AD0E58BF326257E23136466A237138B50|melE]-[gene|05BFEA711D82395A55B505E5A38286BE2F570350|melD]-[gene|4E766839240C8F7D56D87DF9E7B99350A83B5FF7|melC]-[gene|CDE9EF9CFB799794D525F12DEC8C4190C6298575|melA]
description
[Pubmed|22383849]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|22900538]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|22900538], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|58276E6FEF9388BBC7FB79BB5A3A1EF3C3DA5BD5|melR]: repression, [pubmed|31138628], in [regulon|protein:58276E6FEF9388BBC7FB79BB5A3A1EF3C3DA5BD5|melR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|22900538,31138628], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A798 (amyC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/798 NBRP B. subtilis, Japan]
BKE30290 ([gene|4E766839240C8F7D56D87DF9E7B99350A83B5FF7|melC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTTTTTGTACGGGCGG, downstream forward: _UP4_GGTTAACATTAAAGGGGGAA
BKK30290 ([gene|4E766839240C8F7D56D87DF9E7B99350A83B5FF7|melC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCTTTTTGTACGGGCGG, downstream forward: _UP4_GGTTAACATTAAAGGGGGAA
References
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Time of last update: 2024-12-22 08:48:40
Author of last update: Jstuelk