shfA

shfA
168

sporulation heterogeneity factor Antidote, required for sporulation at a late stage

locus
BSU_00610
Molecular weight
24.95 kDa
pI
10.74
Protein length
Gene length
function
control of sporulation entry in neighbor cells
product
sporulation heterogeneity factor Antidote
essential
no
synonyms
yabQ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5869 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
68,515  69,150
Phenotypes of a mutant
inactivation of [gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA] reduces sporulation efficiency to 0.1% that of wild type cells [Pubmed|26735940], this can be suppressed by inactivation of [gene|BA2FA842DAB19E32F48380F56BB772D7E60F2D28|shfP] [https://www.biorxiv.org/content/10.1101/2024.03.27.587046v1.full bioRxiv]
The protein
Structure
[AF|P37559]
[wiki|Localization]
forespore outer membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]-[gene|52D48F22CB53421EE30970D34B4861E2F8A5893D|yabN]-[gene|B0CB19A3E3E84E12BF42BB050394C8A059A89359|rqcP]-[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
description
[Pubmed|11283287]
regulation
expressed during sporulation ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|11283287]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,11283287], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|12207695], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|26577401], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
[protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX]: sigma factor, [Pubmed|12207695], in [regulon|protein:E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX regulon]
Open in new tab

[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]→[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]

2024-09-24 08:34:09

Jstuelk

99

93952be38722510f984794e138450cd80a9f7d48

0CF3909333400A3BFE18E32016883124FFC3D75B

genes
[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
description
[Pubmed|11283287]
regulation
expressed during sporulation ([protein|search|SigE]) [Pubmed|11283287]
additional information
there are about 50,000 molecules of DivIC per cell [http://www.ncbi.nlm.nih.gov/sites/entrez/9426141 PubMed]
Open in new tab

[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]→[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]

2024-07-19 22:46:05

ghost

73

adf8aab8f33a2b64c2ab3f1426fc15c0793898c5

4D8628337CAF16F8F83A7EEB7090199FCE86D5A2

Biological materials
Mutant
MGNA-B918 (yabQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1917 NBRP B. subtilis, Japan]
BKE00610 ([gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00610 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGTATAGAATTGTGTCGTCA,  downstream forward: _UP4_AGATGAAAGGAGGACCGTCT
BKK00610 ([gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00610 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGTATAGAATTGTGTCGTCA,  downstream forward: _UP4_AGATGAAAGGAGGACCGTCT
References
11283287,10869437,15231775,26735940,35638784

4DEDB27C0162409571AB4A1BB17CFE400764AE45

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Time of last update: 2024-10-03 20:35:33

Author of last update: Jstuelk