dgcP
168
diguanylate cyclase
locus
BSU_29650
Molecular weight
65.30 kDa
pI
5.7
function
synthesis of c-di-GMP
product
diguanylate cyclase
essential
no
synonyms
dgcP, ytrP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2199 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,033,696 3,035,435
The protein
Catalyzed reaction/ biological activity
synthesis of c-di-GMP from two molecules of GTP [Pubmed|23893111]
[wiki|Domains]
contains an N-terminal GAF domain [Pubmed|23893111]
contains a C-terminal [wiki|GGDEF domain] [Pubmed|22821967]
Structure
[AF|O34325]
[wiki|Localization]
cytoplasma, forms subcellular clusters at the periphery of exponentially growing cells [pubmed|28536559]
Expression and Regulation
Operons
genes
[gene|4C577B2CEDD9CD2CBFAF036EF36C9EFAF16F923F|dgcP]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-A425 (ytrP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/425 NBRP B. subtilis, Japan]
GP1591 (tet) available in [wiki|Jörg Stülke]'s lab
BKE29650 ([gene|4C577B2CEDD9CD2CBFAF036EF36C9EFAF16F923F|dgcP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTTTATCACCTAAAA, downstream forward: _UP4_TAAAAAAAGCCCAAAACGAT
BKK29650 ([gene|4C577B2CEDD9CD2CBFAF036EF36C9EFAF16F923F|dgcP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTTTATCACCTAAAA, downstream forward: _UP4_TAAAAAAAGCCCAAAACGAT
References
Page visits: 4187
Time of last update: 2024-10-12 12:04:46
Author of last update: Jstuelk