tetB

tetB
168

tetracycline exporter, multifunctional tetracycline/Na+ resistance protein

locus
BSU_40770
Molecular weight
49.59 kDa
pI
9.54
Protein length
Gene length
function
resistance to tetracyclin
product
metal-tetracycline/H+ antiporter
essential
no
synonyms
tetB, tetA, tetA(L)

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,187,681  4,189,057
The protein
Catalyzed reaction/ biological activity
export of tetracyclin (according to Uniprot)
Protein family
[wiki|major facilitator superfamily] (according to UniProt)
[wiki|TCR/Tet family] (according to UniProt)
Structure
[AF|P23054]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|55C9FA5282B213915C164B46119C482D03491381|tetL]-[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]
description
(according to [http://dbtbs.hgc.jp/COG/prom/tetLB.html DBTBS]) null
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2844262], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|55C9FA5282B213915C164B46119C482D03491381|tetL]→[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]

2024-09-21 16:40:11

ghost

86

63c9a5af3eca26ece65b2cd2d340c7272e31a94e

A09189BCE1C3051FC5DFEEAC90EE8300EB8336CB

Biological materials
Mutant
GP2080 (''[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]''::''cat''), available in [wiki|Jörg Stülke]'s lab
GP2081 (''[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]''::''ermC''), available in [wiki|Jörg Stülke]'s lab
BKE40770 ([gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAATTTCCCCTCCATTAA,  downstream forward: _UP4_TAAATGAGTGAAAGGATCAA
BKK40770 ([gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAATTTCCCCTCCATTAA,  downstream forward: _UP4_TAAATGAGTGAAAGGATCAA
labs
[wiki|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Bechhofer%20Laboratory?citype=Physician&ciid=Bechhofer%20David%20H%201255565 Homepage]
References
8631673,10735849,8962071,9988470,8849239,2844262,25169108

4B900A64A96696F48BB0C2DC3B0884CD2F5E298B

Page visits: 4658

Time of last update: 2024-10-07 01:25:04

Author of last update: Jstuelk