nadE
168
NH3-dependent NAD+ synthetase
locus
BSU_03130
Molecular weight
30.24 kDa
pI
4.89
function
NAD biosynthesis
product
NH3-dependent NAD+ synthetase
essential
yes
ec
6.3.1.5
synonyms
nadE, outB, tscBGH, gsp-81
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0171 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
338,288 339,106
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + deamido-NAD+ + NH4+ --> AMP + diphosphate + H+ + NAD+ (according to UniProt)
Protein family
NAD synthetase family (single member, according to UniProt)
Structure
[PDB|1EE1] [pubmed|11375500]
[AF|P08164]
Expression and Regulation
Operons
genes
[gene|4B74B1653D783779AFB37EDF9D33E7D6F1AC92B5|nadE]
description
[Pubmed|2435704]
regulation
induced by antibiotics interacting with the cytoplasmic membrane [Pubmed|22926563]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|9271869,11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
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Time of last update: 2024-12-19 06:35:44
Author of last update: Jstuelk